检测血管紧张素转化酶在AFP阴性肝癌诊断中的价值  

The serum activity of angiotensin - converting enzyme in diagnosis of AFP - negative HCC patients

作　　者：周爱国 黄玉波 王开贺 徐本峰 宋思琴 魏红山[3] 

机构地区：[1]山东省枣庄市中区医院,277100 [2]山东省枣庄市峰城医院 [3]上海第二医科大学新华医院

出　　处：《实用肝脏病杂志》2003年第1期19-20,共2页Journal of Practical Hepatology

摘　　要：目的 近期研究显示,多种恶性肿瘤患者血清血管紧张素转化酶(ACE)活性降低。本研究旨在探讨肝癌患者血清ACE活性变化对AFP阴性肝癌(HCC)患者诊断及鉴别诊断的价值。方法观察对象为经组织学(肝穿刺)或影象学确诊的38例HCC患者、21例慢性肝炎患者12例肝硬化患者及20例正常健康对照者。血清AFP和ACE活性均按试剂盒说明书进行。结果与其他良性肝病相比,HCC患者血清ACE活性(19.51±4.46)显著低于慢性肝炎(38.35±6.34,p<0.01)及肝硬化患者(47.77±10.59,P<0.01),也低于正常人(30.00±2.92,P<0.05)。23例AFP阳性(≥200μg/L)HCC患者中,其ACE活性为(19.15±4.26),与15例AFP阴性患者的ACE活性(20.06±4.85)无差异(P>0.05)。结论 检测血清ACE活性有助于肝癌,尤其是合并肝硬化或AFP阴性的患者的诊断,联合检测ACE和AFP有助于提高肝癌的检出率。Objective Recently, a number of studies have demonstrated that serum activity of angiotensin- converting enzyme (ACE) significantly decreases in patients with carcinoma of different localizations. There is no information in literature about measuring this enzyme in hepatocullular carcinoma patients. Methods The serum activity of ACE was examined in 38 patients with primary liver carcinoma,21 patients with chronic hepatitis, and 20 healthy subjects. Results The serum activity of ACE increased in patients with cirrhosis (47.77± 10.59,P< 0.01),and in chronic hepatitis (38. 35 ± 6.34, P < 0.01)and decreased in hepatocellular carcinoma patieats(19.51 ±4.46).There is no difference between AFP- positive (≤200μg/L) and AFP- negative( < 200μg/L) patients.Conclusion These results suggests that we can measure serum ACE activity as one of hepatocullular carcinoma marker in diagnosis of the liver disease, especially in AFP- negative cirrhotic patients.

关 键 词：原发性肝癌 诊断 血管紧张素转化酶 血清标志物 

分 类 号：R735.7[医药卫生—肿瘤]