巨细胞病毒感染胎盘的免疫病理观察  

Immunopathological Study on Human Placenta with Cytomegalovirus Infection

作　　者：张睿[1] 陈志辽[1] 刘颖琳[1] 李海刚[1] 

机构地区：[1]中山大学附属第二医院,广州510120

出　　处：《中国医药导报》2005年第18期12-13,共2页China Medical Herald

摘　　要：目的探讨人巨细胞病毒(HCMV)感染胎盘的病理变化及其在HCMV宫内传播中的意义。方法HCMV感染孕妇的胎盘组织作常规HE染色及HCMVIEA和EA免疫组织化学染色,观察其病理变化。结果HCMV感染胎盘表现不同程度的绒毛炎或正常,未见典型巨细胞包涵体。HCMV抗原阳性染色见于绒毛毛细血管内皮细胞、Hofbauer细胞、其他间质细胞和合体滋养细胞。结论HCMV在胎盘屏障细胞中的序列传播和绒毛胎血屏障的破坏可能是其宫内传播的途径。Objective To study the pathological changes of placenta with human cytomegalovirus (HCMV) infection and the role of placenta in the intrauterine transmission of HCMV.Methods Histologic examination and immunocytochemistry to HCMV immediate early antigen and early antigen were used to characterize placental involvement in 30 mothers with HCMV infection. Results On routine histologic evaluation, non - specific villitis or no pathologic changes were shown in infected placentas. Diagnostic viral inclusion was unfound. Immunoperoxidase staining showed infection in the capillary endothelial cells, Hofbauer cells, other villous stro mal cells and syncytiotrophoblasts. Conclusion The sequence transmission of HCMV in placental barrier cells or wreck of placental barrier may be the routes of intrauterine transmission of HCMV.

关 键 词：巨细胞病毒感染 胎盘病理 免疫组织化学 

分 类 号：R[医药卫生]