中药肝豆汤对遗传性肝豆状核变性患者铜锌代谢的影响  

The effect of Gandou decoction on intracellular contents change of copper－ zinc in vitro model of cultured hepatocell of hepatolenticular degeneration

作　　者：刘康永[1] 韩咏竹[2] 杨任民[2] 

机构地区：[1]复旦大学医学院附属华山医院,上海200233 [2]安徽中医学院神经病学研究所

出　　处：《中国组织工程研究与临床康复》2001年第13期49-50,共2页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金资助项目 (39570878)

摘　　要：目的 在细胞水平探讨中药复方肝豆汤治疗肝豆状核变性 (HLD)的机制。方法 在以 HLD患者的肝脏制备的肝细胞模型中加入含肝豆汤兔血清，观察加入前后细胞模型中铜锌等微量元素含量的变化。结果 加入含肝豆汤兔血清 24h后细胞内铜含量明显减少，锌含量明显增加。结论 肝豆汤具有显著的细胞内排铜作用，同时可使细胞内锌含量显著增加。Objective To explore the cytological mechanism of Gandou decoction(GDD)treating HLD(hepatolenticular degeneration).Method We established the vitro models of cultured hepatocell of HLD,fourteen in vitro models of cultured hepatocell of HLD were established to observe the intracellular change of micuoelements(Cu2＋ ,Zn2＋ ,etc)contents before and after adding rabbit serum containing GDD.Result After treatment with GDD containing serum for 24 hours,the intracellular content of Cu2＋ decreasde Zn2＋ increased.Conclusion GDD is quite effective in removing the intracellular copper and increasing the intracellular zinc.

关 键 词：肝豆状核变性 肝豆汤 含肝豆汤兔血清 肝豆状核变性肝细胞模型 细胞内铜锌含量 

分 类 号：R742.4[医药卫生—神经病学与精神病学]