Effect of Dachengqi Granules (大承气汤颗粒剂) on Level of Endotoxin in Ente rogenous Endotoxemia in Rats  

作　　者：LIN Xiu-zhen(林秀珍) ZHENG Yao(郑尧) MA De-lu(马德禄) XIE Wen-li(谢文利) ZHAO Shan(赵珊) WU Xian-zhong(吴咸中) 

机构地区：[1]Department of Pharmacology, Tianjin Medical University,Tianjin (300070), China Department of Pharmacology, Tianjin Medical University,Tianjin (300070), China Department of Pharmacology, Tianjin Medical University,Tianjin (300070), China Department of Pharmacology, Tianjin Medical University,Tianjin (300070), China Department of Pharmacology, Tianjin Medical University,Tianjin (300070), China Department of Pharmacology, Tianjin Medical University,Tianjin (300070), China

出　　处：《Chinese Journal of Integrative Medicine》2002年第4期299-301,共3页中国结合医学杂志（英文版）

基　　金：DepartmentofPharmacology;TianjinMedicalUniversity;Tianjin(30 0 0 70);China

摘　　要：Objective:To study the effect of Dachengqi Granule (DCQG) on endotoxin level in rats of enterogenous endotoxemia.Methods: Enterogenous endotoxemia model of rats was mad e by peritoneal injection of E.coli. In the treated groups, the rats were treat ed with different doses of DCQG, cefaclor and DCQG plus cefaclor respectively, starting from 3 days before to 1 day after modeling. Endotoxin levels in plasma, urine and stool were determined and compared. Results: Except for the cefaclor group, the plasma and urine endotoxin levels in the treated groups were lower significantly ( P <0.0 5), while the endotoxin level in stool was obviously higher than that in the unt reated model group.Conclusion:DCQG has the intestinal barrier protective e ffect including anti-bacteria, anti-inflammation and clearing endotoxin.Objective:To study the effect of Dachengqi Granule (DCQG) on endotoxin level in rats of enterogenous endotoxemia.Methods: Enterogenous endotoxemia model of rats was mad e by peritoneal injection of E.coli. In the treated groups, the rats were treat ed with different doses of DCQG, cefaclor and DCQG plus cefaclor respectively, starting from 3 days before to 1 day after modeling. Endotoxin levels in plasma, urine and stool were determined and compared. Results: Except for the cefaclor group, the plasma and urine endotoxin levels in the treated groups were lower significantly ( P <0.0 5), while the endotoxin level in stool was obviously higher than that in the unt reated model group.Conclusion:DCQG has the intestinal barrier protective e ffect including anti-bacteria, anti-inflammation and clearing endotoxin.

关 键 词：Dachengqi Granule enterogenous  endotoxemia ENDOTOXIN RAT 

分 类 号：R3[医药卫生—基础医学]