云南高疟区抗疟药物临床研究中适宜恶性疟原虫密度范围的观察  

Observation on proper parasite density of Plasmodium falciparum for clinical trials of antimalarial drugs in Yannan

作　　者：张再兴[1] 李丽[1] 黄国珍[1] 周升[1] 孙晓东[1] 李崇珍[1] 杨亚明[1] 

机构地区：[1]云南省疟疾防治研究所,思茅665000

出　　处：《医学动物防制》2001年第4期198-202,共5页Journal of Medical Pest Control

摘　　要：通过对云南一恶性疟暴发点病人血液中无性体和有性体的观察发现,当地恶性疟无性体密度初发者几何平均值为1798/μl,95％可信限为1141～2836/μl,复燃者的几何平均密度为6540/μl.95％可信限为4230～10097/μl;初发者的无体密度比复燃者的低,复燃者高密度居多。有性体密度初发者几何平均值为158/μl,95％可信限为102～247/μl;初发者有体性密度比复燃的高。初发者有性体率为57.69％,复燃者仅为9.1％。原虫无性体与有性体密度间不存在统计相关。建议在选择无服抗疟药史者为观察对象.以有服抗疟药史者为观察对象,以及两类病人同时均作为观察对象时,宜分别以1000～3000/μl,4000～10000/μl和1000～10000/μl为无性体密度的适宜范围。而观察有性机体时,则以100～300/μl为其适宜密度范围。It is found that the geometric mean of asexual parasite density for new cases is 1798//J, 95% CI is 1141~2836/ul; the geometric mean of asexual parasite density for recrudescent cases is 6540//al, 95% CI is 4230-10097/jul. The geometric mean of sexual parasite density for new cases is 158//J, 95% CI is 102-247/ul; the density of new cases is higher than of recrudent cases. The sexual parasite rate for new cases is 57. 69% and 9. 0% for recrudescent cases. There was no relation between the density of asexual and sexual parasites. It is suggested that when selecting patients without antimalarial drugs taking history, with antimalarial taking history,and selecting both kind of patients, the proper a sexual parasite density range for them is 1000-3000/u1, 4000 - 10000/ul, and 1000 -10000/ul, respectively. For observation on sexual parasite, the proper density range is 100 -300/u1.

关 键 词：抗疟药物 临床研究 恶性疟原虫 密度 

分 类 号：R[医药卫生]