跨膜糖蛋白V6在卵巢上皮癌中的表达及意义  

The clinical significance of CD44 V6 protein expression in ovarian epithelial carcinoma

作　　者：王晶[1] 隋丽华[1] 高庆玉[1] 杨宏伟 

机构地区：[1]哈尔滨医科大学第三临床学院,150040 [2]大庆四院

出　　处：《中国妇产科临床杂志》2001年第1期16-18,共3页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的 探讨跨膜糖蛋白V6(CD44 V6)在卵巢上皮癌中的表达及意义。方法 应用CD44 V6的单克隆抗体,以SP免疫组织化学方法,对35例卵巢上皮癌、18例卵巢上皮瘤和15例正常卵巢组织的石蜡标本做CD44 V6的检测,并分析卵巢上皮癌的临床病理资料。结果①卵巢组织CD44 V6呈阴性表达,卵巢上皮瘤中可有CD44 V6表达,正常卵巢与卵巢良性肿瘤之间的表达有显著性差异(P<0.01);卵巢上皮癌与卵巢上皮瘤相比CD44 V6表达呈升高趋势,但不具有统计学意义(P>0.05);②CD44V6的表达与卵巢上皮癌的临床分期有关(P<0.05),与组织分化程度及病理类型无关(P>0.05);③CD44 V6的表达与卵巢上皮癌的预后有关(P<0.05)。结论CD44 V6可能是卵巢上皮癌发生的相关基因,与肿瘤发展及转移有关;检测CD44 V6可以估计卵巢上皮癌患者的预后,指导临床化疗。Objective To investigate CD44 V6 expression in ovarian epithelial carcinoma. Methods Monoclonal an-tibody anti - CD44 Y6 were used in immunohistochemical stainings of paraffin embedded tissue sections of 35 ovarian epithelial carcinomas, 18 benign ovarian epithelial tumors and 15 normal ovaries as controls. The clinical pathological materials of ovarian epithelial carcinoma were also studied. Results ①There was no expression of CD44 V6 in normal controls, but positive expressions in some ovarian epithelial tumors. ②CD44 V6 positive expression was correlated with the clinical staging of ovarian epithelial carcinoma (P < 0.05), but was not correlated with the differentiation and histopathological classification (P > 0.05) .③The overexpression of CD44 V6 was also correlated with prognosis of ovarian epithelial carcinoma (P < 0.05) . Conclusions CD44 V6 may be correlated with the occurrence of ovarian epithelial carcinoma, the advancement as well as the metastasis. The measurement of CD44 V6 can be used to evaluate the prognosis of ovarian epithelial carcinoma and to help for chemotherapy.

关 键 词：CD44 V6 卵巢上皮癌 免疫组化 预后 

分 类 号：R737.31[医药卫生—肿瘤]