抗癌消水膏外敷对人肺腺癌A549细胞裸小鼠胸膜转移模型的影响  

An experimental studies of external used Kangaixiaoshui plaster treating malignant pleural effusion

作　　者：程志强[1] 贾立群[1] 杜秀平[1] 赵炜[1] 李佩文[1] 张代钊[1] 郝迎旭[1] 于莉莉[1] 

机构地区：[1]中日友好医院中医肿瘤科,北京100029

出　　处：《癌症进展》2003年第2期157-160,共4页Oncology Progress

摘　　要：目的 观察抗癌消水膏外敷对人肺腺癌A549细胞裸小鼠胸膜转移模型生存期和生存质量的影响。方法 建立人肺腺癌A549细胞裸小鼠胸膜转移模型,共分3组,每组各10只,即基质对照组、顺铂治疗组、抗癌消水膏外敷组。另用10只以同等重量的未接种肿瘤的裸小鼠作为健康对照组。观察4组小鼠体重、摄食量、生存期以及肿瘤细胞在胸膜腔的浸润程度。结果 ①抗癌消水膏外敷后肿瘤细胞在胸腔里的浸润程度明显减轻,与基质对照组比有显著差异(P<0.01)。对小鼠体重、摄食量各组之间也有一定的差异;②延长小鼠生存期:DDP组中位生存时间为36天,抗癌消水膏组为43天。抗癌消水膏组中位生存时间明显长于顺铂治疗组(P<0.01)。结论 抗癌消水膏外敷治疗能延长模型小鼠的生存时间,提高模型小鼠的生活质量。To study the effect and mechanism of Kangaixiaoshui Plaster treating malignant pleural effusion by animal experiments. Methods The pleura metastasis model of human pulmonary adenocarcinoma A549 in nude mouse was established. Thirty nude mice were divided into base control group, Cisplatin group and Kangaixiaoshui Plaster group. Meanwhile, 10 mice without any treatment were involved as healthy control group. The body weight, food intake, survival time and infiltration of tumor cells in pleural cavity of all of the mice were observed. Results ①The infiltration of tumor cells in pleural cavity decreased in Kangaixiaoshui Plaster group and there was significant difference compared with the control groups.②The median time in Kangaixiaoshui Plaster group, was 43 days, which was significantly largerer than 36 days in the Cisplatin group. Conclusion Kangaixiaoshui Plaster used externally is effective in treating malignant pleural effusion. It can prolong the survival time and improve the quality of life (QOL) of nude mouse with malignant pleural effusion.

关 键 词：抗癌消水膏 肺腺癌 癌性胸腔积液 动物模型 裸鼠 

分 类 号：R734.2[医药卫生—肿瘤]