恶性肿瘤生物化疗及其临床应用类别  

Bio-chemotherapy and clinical application categories for malignancy

作　　者：李卫东 李金瀚 

机构地区：[1]广州市肿瘤医院化疗科,广州510095

出　　处：《癌症进展》2003年第4期202-205,共4页Oncology Progress

摘　　要：随着化疗和生物治疗研究的进展,人们在思考如何把生物治疗与化学治疗相结合治疗恶性肿瘤。单用或与化疗相结合的生物治疗药物有:细胞因子、造血生长因子、树突状细胞、表皮生长因子受体-酪氨酸激酶抑制剂、血管抑素和内皮抑素、基质金属蛋白酶抑制剂、细胞信号通路调节剂、反义治疗药物、单克隆抗体靶向药物和基因治疗等。恶性肿瘤生物化疗的临床应用类别包括:同步性生物化学疗法,序贯性生物化学疗法和化疗失败后的补救性生物治疗。The biotherapy combination with chemotherapy for malignancy should be recently considered, along with research progress in chemotherapy and biotherapy. Biotherapy drugs alone or combination with chemotherapy include: cytokines, hematopoietic growth factors, dentritic cell, epidermal growth factor receptor-tyrosine ki-nase inhibitors (EGFR-TKIs), angiostatin and endostatin, matrix metalloproteinases (MMPs), modulatin of signal transduction pathway, antisense therapeutic agents, monoclonal antibody target agents and genetherapy. The clinical application categories include: concurrent bio-chemotherapy, sequential bio-chemotherapy and salvage biotherapy after chemotherapy failure.

关 键 词：恶性肿瘤 生物治疗 化学治疗 

分 类 号：R730.53[医药卫生—肿瘤]