声门型低分化喉癌21例临床观察  

Clinical analysis of 57 patients with poorly differentiated carcinomas of the glottis

作　　者：刘文胜[1] 唐平章[1] 祁永发[1] 徐震纲[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院头颈外科,北京100021

出　　处：《癌症进展》2004年第3期225-227,共3页Oncology Progress

摘　　要：目的探讨声门型低分化喉癌的临床特点、治疗及预后。方法 回顾分析我院21例声门型低分化喉癌病例。结果3年和5年生存率分别为57.1％(12/21)和47.1％(8/17),局部复发率为23.8％(5/21),累计颈淋巴结转移率为47.6％(10/21)。有颈淋巴结转移和无颈淋巴结转移患者的5年生存率分别为12.5％(1/8)和77.8％(7/9),存在显著性差异(X2=4.866,P=0.027)。喉部分切除手术的局部复发率为18.2％(2/11),其中6例结合放射治疗均无复发。结论声门型低分化喉癌颈淋巴结转移率高,预后相对较差,建议采用手术结合放射治疗,喉部分切除手术是可行的,颈部N0的患者应行选择性治疗。Objective To determine the clinical characteristic, treatment and prognosis for poorly differentiated carcinomas of the glottis. Methods A retrospective review was conducted in 21 cases of poorly differentiated carcinomas of the glottis treated in our hospital. Results The overall 3-and 5-year survival rates for the entire series of patients were 57.1 % (12/21) and47.1% (8/17), respectively. The locally recurrent rate and cervical metastasis rate were 23.8 % (5/21) and 47.6% (10/21), respectively. The difference in the 5-year survival rates for the patients with and without cervical metastasis, 12.5% (1/8) and 77.8% (7/9), respectively, were statistically significant (X2=4.866, P= 0.027). The locally recurrent rate for partial laryngec-tomy was 18.2% (2/11) and all of patients with partial laryngectomy combined with radiotherapy had no recurrence . Conclusion The patients with poorly differentiated carcinomas of the glottis had high cervical metastasis rate and poor prognosis. The combined therapy with surgery and radiation was supposed to be a priority . The partial laryngectomy was feasible to perform on certain patients. The selective cervical treatment for the patients with poorly differentiated carcinomas of the glottis was recommended.

关 键 词：喉肿瘤 低分化 外科手术 放射治疗 

分 类 号：R739.65[医药卫生—肿瘤]