宫颈癌的同步放化疗  

Concurrent chemoradiation for cervical cancer

作　　者：黄曼妮[1] 吴令英[1] 高菊珍[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院妇瘤科,北京100021

出　　处：《癌症进展》2004年第5期320-326,共7页Oncology Progress

摘　　要：早期宫颈癌的主要治疗方式是手术 ,而放疗是中晚期宫颈癌的主要治疗手段。近年来一系列随机分组研究表明 ,中晚期宫颈癌应用以顺铂为基础的同步放化疗较单纯放疗明显改善生存率 ,使死亡危险下降 30 %～ 5 0 %。对具有高危因素的早期宫颈癌进行术后同步放化疗较单纯放疗、单纯化疗提高了疗效。至于放疗前新辅助化疗的疗效 ,目前研究结果表明未能改善生存。如何改进治疗 ,特别是选用放疗中联合应用的最佳化疗方案均需进一步研究。Surgery is the major treatment in the early stage cervical cancer.Radiotherapy is a very important treatment in the advance stage cervical cancer.Recently,a series of randomized trials has been demonstreted that in the patients with advanced-stage cervical cancer,concurrent use of cisplatin-based chemotherapy with radiotherapy show an overall survival advantage and reduced the risk of death by 30%～50% compared with radiation alone.In the resected early-stage cervical cancer with high risk factors,chemoradiotherapy show benefit compared with radiation or chemotherapy alone.Chemotherapy followed by radiotherapy(Neoadjuvant chemotherapy)failed to improve the survival compared with radiotherapy alone.However,further studies are necessary to optimize treatment schedules and particularly to define the best drug combination to be used during radiation therapy.

关 键 词：宫颈癌 同步放化疗 

分 类 号：R737.33[医药卫生—肿瘤]