固本消瘤胶囊配合化疗治疗晚期非小细胞肺癌的临床研究  被引量：4

inical study of the Guben Xiaoliu Capasule effects in the treatment of advanced non-small cell lung cancer</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=1001083396' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('L/TRNcl+RJswK4OoMVUaGMC2Hkx//Y7Lv43MWdmYLJ+AKrwHEXjwlg==')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="L/TRNcl+RJswK4OoMVUaGMC2Hkx//Y7Lv43MWdmYLJ+AKrwHEXjwlg=="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" name="collRemark" id="collSumRemark" /> </p> <p style="text-align: center;"> <a href="javascript:void(0)" onclick="g_collectSumOk();"> <img width="65" height="17" src="/images_new/collect_ok.png" alt="完成" /></a> <a href="javascript:void(0)" onclick="g_collectSumCancel();"> <img width="65" height="17" src="/images_new/collect_no.png" alt="取消" /></a> </p> </div> </div> </div> <form name="wxTransfer" method="post"> <input type="hidden" name="lid" value="" /> <input type="hidden" name="sip" value="" /> <input type="hidden" name="date" value="" /> <input type="hidden" name="co" value="" /> <input type="hidden" name="Title_C" value="" /> <input type="hidden" name="Writers" value="" /> <input type="hidden" name="Name_C" value="" /> <input type="hidden" name="Num" value="" /> <input type="hidden" name="Years" value="" /> <input type="hidden" name="Volumn" value="" /> <input type="hidden" name="GCH" value="" /> <input type="hidden" name="Vol" value="" /> <input type="hidden" name="BookID" value="" /> <input type="hidden" name="SubjectNum" value="" /> <input type="hidden" name="SpecialNum" value="" /> <input type="hidden" name="mirrorName" value="" /> <input type="hidden" name="UserID" value="" /> <input type="hidden" name="UserName" value="" /> <input type="hidden" name="sourceID" value="" /> </form> <script type="text/javascript" src="/scripts/transfer.min.js"></script> <div class="article-detail"> <p class='author'><strong>作　　者：</strong><a href='/writer/article.aspx?id=100000012175005' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%8e%8b%e7%ac%91%e6%b0%91%5d' title='王笑民[1]'>王笑民[1]</a> <a href='/writer/article.aspx?id=100000011450619' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%83%81%e4%bb%81%e5%ad%98%5d' title='郁仁存[1]'>郁仁存[1]</a> <a href='/writer/article.aspx?id=100000029431614' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%be%9b%e6%b5%b7%5d' title='辛海[1]'>辛海[1]</a> <a href='/writer/article.aspx?id=100000011157858' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%9d%a8%e5%9b%bd%e6%97%ba%5d' title='杨国旺[1]'>杨国旺[1]</a> <a href='/writer/article.aspx?id=100000001571435' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%b5%b5%e6%96%87%e7%a1%95%5d' title='赵文硕[1]'>赵文硕[1]</a> <a href='/writer/article.aspx?id=100000001046778' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%ad%99%e4%b9%a6%e8%b4%a4%5d' title='孙书贤[1]'>孙书贤[1]</a> <a href='/writer/article.aspx?id=100000007237011' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%88%98%e7%82%ac%5d' title='刘炬[1]'>刘炬[1]</a> <a href='/writer/article.aspx?id=100000007578795' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%9d%a8%e4%b8%ad%5d' title='杨中[1]'>杨中[1]</a> <a href='/writer/article.aspx?id=100000001027204' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%94%90%e6%ad%a6%e5%86%9b%5d' title='唐武军[1]'>唐武军[1]</a> <a href='/writer/article.aspx?id=100000015409420' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%bc%a0%e9%9d%92%5d' title='张青[1]'>张青[1]</a> <a href='/writer/article.aspx?id=100000005977756' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%83%a1%e5%87%a4%e5%b1%b1%5d' title='胡凤山[1]'>胡凤山[1]</a> <a href='/writer/article.aspx?id=100000007081135' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%9f%a9%e5%86%ac%5d' title='韩冬[1]'>韩冬[1]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=1999&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%8c%97%e4%ba%ac%e4%b8%ad%e5%8c%bb%e5%8c%bb%e9%99%a2%e8%82%bf%e7%98%a4%e7%a7%91' title='[1]北京中医医院肿瘤科,北京100010'>[1]北京中医医院肿瘤科,北京100010</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=88329X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e7%99%8c%e7%97%87%e8%bf%9b%e5%b1%95%5d' title='癌症进展'>《癌症进展》</a>2004年第6期455-457,454,共4页<em>Oncology Progress</em></p><p class='abstrack'><strong>摘　　要：</strong>目的 观察固本消瘤胶囊治疗晚期非小细胞肺癌(NSCLC)的临床疗效。方法 102例晚期NSCLC住院患者随机分为固本消瘤胶囊加化疗组(A组54例),化疗组(C组48例)。选择拒绝化疗、单纯口服固本消瘤胶囊组(B组96例),进行对照观察。结果 A、B、C组近期有效率分别为16.7％、3.1％、8.4％,A组优于C组,P<0.05,且A、B两组患者在临床症状变化、生活质量方面均优于C组,P<0.05。中位生存期A、B、C组分别为12个月,15个月和9个月。治疗后1、2、3年生存率,A组分别为57.4％、11.1％和3.7％;B组分别为67.7％、9.38％和3.13％;C组1、2年生存率分别为39.6％、4.17％,3年生存率为0。经统计学处理,A组和B组的生存率优于C组,P<0.05。A组的化疗毒副作用较C组明显减轻。结论 固本消瘤胶囊对NSCLC具有一定的客观疗效,主要表现为稳定病灶、提高生活质量、延长生存期;该制剂与化疗联合应用有明显的增效减毒作用。<em><abstract>jective To observe the effect of Guben Xiao liu Capsule (GBXLC) in the treatment of advanced non small cell lung cancer (NSCLC). Methods 198 NSCLC patients were divided randomly into three groups. They are group A, GBXLC plus chemotherapy; group B, GBXLC alone, group C, chemotherapy alone. Results The response rate in three groups was16.7%, 3.1%, and 8.4% respectively. The response rate in group A was better than that in group C. After treatment, the symptoms, KPS, were all improved in group A and group B, better than that in group C. The median survival time in three groups was 15, 12 and 9 months respectively. The 1-year、2-year and 3-year survival rate in group A were 57.4%, 11.1% and 3.7%; in group B were 67.7% , 9.38% and 3.13% ; in group C were 39.6% , 4.17% , and 3-year survival rate is 0. The chemotherapeutic toxicities were mainly bone marrow depression, decrease of WBC, gastrointestinal disturbance and hair loss. But the toxicity occurring rate and toxic degree was much sh'ghter in group A thanthat in group C. Conclusion GBXLC can be used for NSCLC treating. It may stable the cancer lesion, relieve the symptoms, improve quality of life and prolong survival time. GBXLC may strengthen the efficacy of chemotherapy and relieve the side effects of chemotherapy.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=6164757' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%9b%ba%e6%9c%ac%e6%b6%88%e7%98%a4%e8%83%b6%e5%9b%8a%5d' title='固本消瘤胶囊'>固本消瘤胶囊</a> <a href='/subject/article.aspx?id=6712601' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%5d' title='非小细胞肺癌'>非小细胞肺癌</a> <a href='/subject/article.aspx?id=1990026' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e7%94%9f%e5%ad%98%e6%9c%9f%5d' title='生存期'>生存期</a> <a href='/subject/article.aspx?id=1995137' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e7%94%9f%e6%b4%bb%e8%b4%a8%e9%87%8f%5d' title='生活质量'>生活质量</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR730.52' title='R730.52'>R730.52</a>[<a href = '/domain/article.aspx?id=503' >医药卫生—肿瘤</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=1001083396" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=1001083396"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); if (rd == "readdown") { var val = $("#hiddowninfo").val(); showdown(val); } $("#bdshare_js").attr("src","http://bdimg.share.baidu.com/static/js/bds_s_v2.js?cdnversion="+Math.ceil(new Date() / 3600000)); }) </script> <div class="layer-bg" style="display: none;"></div> <script type="text/javascript" src="/scripts/login.min.js"></script> <div class="layer-box login" id="divLoginBox" style="display: none;"> <div class="close"><a href="javascript:void(0);" id="btnLoginClose"> <img src="/images/layer-close.png" width="21" height="21" alt="" title="关闭" /></a></div> <h5 class="layer-title">用户登录</h5> <div class="layer-cnt"> <div class="search-list adv-object"> <div class="login-alert" id="divLoginError"></div> <div class="sinput"> <div class="input"><span class="user-ico"></span> <input type="text" id="txtLUsername" name="txtLUsername" maxlength="20"></div> </div> <div class="sinput"> <div class="input"><span class="psw-ico"></span> <input type="password" id="txtLPassword" name="txtLPassword" maxlength="20"></div> </div> <div class="submit"> <input type="button" value="登录" onclick="return normalLogin(loginAfter)" name="" class="btn-s"><input value="IP登录" onclick=" return ipLogin(loginAfter)" type="button" class="btn-c"> </div> </div> </div> </div> <div id="footer"> <p> 云南高校图书馆联盟文献共享服务平台 版权所有© <script type="text/javascript"> document.write(new Date().getFullYear()); </script> </p> <p> 您的IP：3.21.125.194 </p> </div> <input id="hifBaseLog" type="hidden" value="ODgzMjlYOzEwMDEwODMzOTY7UjczMC41MjswOzsvYXJ0aWNsZS9kZXRhaWwuYXNweA=="/> <script type="text/javascript"> $(document).ready(function () { $("#loginLoading").load("/user/loginheader.aspx?" + Math.random()); }); </script> <script> var _hmt = _hmt || []; (function () { var hm = document.createElement("script"); hm.src = "//hm.baidu.com/hm.js?36a05ff8f5e8a5be3ff03e1d75c8a9d1"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); </script> <script> (function (i, s, o, g, r, a, m) { i['GoogleAnalyticsObject'] = r; i[r] = i[r] || function () { (i[r].q = i[r].q || []).push(arguments) }, i[r].l = 1 * new Date(); a = s.createElement(o), m = s.getElementsByTagName(o)[0]; a.async = 1; a.src = g; m.parentNode.insertBefore(a, m) })(window, document, 'script', '//www.google-analytics.com/analytics.js', 'ga'); ga('create', 'UA-2219013-37', 'auto'); ga('send', 'pageview'); </script> </body> </html>