三氧化二砷治疗复发难治性急性早幼粒细胞白血病临床疗效观察  

Effect of arsenic trioxide on the treatment of relapsed acute promyelocytic leukemia

作　　者：马军[1] 展昭民[1] 梁红[1] 贡铁军[1] 唐庆华[1] 任实[1] 郝文鹏[1] 靳明华[1] 夏国强[1] 邵秀茹[1] 王来慈[1] 张伯龙[1] 

机构地区：[1]哈尔滨血液病肿瘤研究所,哈尔滨150010

出　　处：《癌症进展》2005年第2期98-101,共4页Oncology Progress

摘　　要：目的　探讨三氧化二砷治疗复发难治性急性早幼粒细胞白血病 (APL)的疗效。方法　 1988～ 2 0 0 0年 1月对 388例复发的APL给予三氧化二砷治疗 (10mg) ,连续用药至完全缓解。结果　应用三氧化二砷治疗的 388例复发APL中完全缓解 (CR)率为 74 13% ,部分缓解 (PR)率 10 14 % ,CR+PR为 84 2 7% ,预计 10年无病生存率为 6 9%。早期死亡率及治疗相关死亡率分别为 7%、 10 %。主要死亡原因是脑出血、DIC、脑梗死。本组高白细胞综合征发生率为 15 %。副作用主要是消化道症状 ,发生率为 2 6 % ,肝功能损害发生率为 9% ,肾功能损害 6 % ,心电图改变 16 % ,精神症状 7%。结论　临床研究表明三氧化二砷是治疗复发APL最有效的药物之一 ,并可治愈APL。Objective To study the effect of arsenic trioxide on patients with relapsed acute promyelocytic leukemia(APL)。Methods From 1988 to 2000 January,388 patients were received arsenic trioxide(10mg),up to get complete remission.Results Among the 388,the complete remission(CR)rate was 74.13%,partial remission(PR)rate was 10.14%,CR+PR rate was 84.27%,expected 10 years diseas-free survival rate was 68%.The early death rate and treatment-related mortality was 7% and 10% respectively.The major causes of death were cerebral hemorrhage,DIC,cerebral infarction and infection.Fifteen percent of this group of patients manifested hyperleukocytosis.The major side effects were gastrointestinal indisposition(26%),liver function damage(19%),renal function damage(6%),abnormality of ECG(16%)and mental abnormality(7%).This study indicated that arsenic trioxide is one of the most effective medications for relapsed APL patients,which may also lead to the cure of APL patients.

关 键 词：急性早幼粒细胞白血病 三氧化二砷 

分 类 号：R733.71[医药卫生—肿瘤] R730.53[医药卫生—临床医学]