首发抑郁症血清褪黑激素水平的初步研究  

A preliminary study of serum melatonin levels of first-episode depressive patients

作　　者：卞茜[1] 张明岛[1] 王克勋[1] 

机构地区：[1]上海市精神卫生中心,200030

出　　处：《上海精神医学》2003年第3期129-131,共3页Shanghai Archives of Psychiatry

基　　金：20 0 2年上海市卫生局青年课题基金资助

摘　　要：目的　检测首发抑郁症发作时 ,使用SSRI类抗抑郁剂后的褪黑激素水平 ,并探讨用放免作为测定抑郁症褪黑激素水平有效方法的可能性。方法　对 18例首发抑郁症、13例首发精神分裂症和 17例正常志愿者采用放射免疫法检测其血清褪黑激素水平。结果　首发抑郁症抑郁发作时血清褪黑激素水平显著低于对照首发精神分裂症组 ,治疗后血清褪黑激素水平有显著升高。结论　褪黑激素在抑郁症的发病机制中起一定作用 。Objective: The aim of study is to determine the melatonin levels of first episode depressive patients at acute onset and after the use of SSRI antidepressants. Methods: Using radioimmunoassay, serum levels of melatonin were determined in 18 depressive and 13 schizophrenic patients of first episode and 17 healthy volunteers. Results: Compared with schizophrenic controls of first episode, serum level of melatonin at acute onset was significantly lower in depression and improved significantly after the treatment. Conclusion: Decreased serum level of melatonin may be a part of the pathological mechanisms of depression. Radioimmunoassay is an efficiency method to determine the levels of melatonin in depression.

关 键 词：抑郁症 褪黑激素 放射免疫法 

分 类 号：R749.4[医药卫生—神经病学与精神病学]