盐酸氟西汀治疗强迫症63例临床疗效及安全性  

Clinical effectivensess and safety of fluoxetine hydrochloride in treating 63 patients with obsessive compulsive disorder

作　　者：杨晓敏[1] 江开达[1] 周卉[1] 王志阳[1] 凌政[1] 

机构地区：[1]上海市精神卫生中心,200030

出　　处：《上海精神医学》2003年第4期218-219,203,共3页Shanghai Archives of Psychiatry

摘　　要：目的　观察盐酸氟西汀治疗强迫症的临床疗效及不良反应。方法　对 6 3例强迫症患者予盐酸氟西汀治疗 ,以Y BOCS减分率作为疗效评定 ,以TESS量表评定不良反应。结果　 6 3例患者经 8周治疗后Y BOCS、HAMD、HAMA、NIMH总分均较治疗前有显著性差异。痊愈 (12 % )、显进(2 7% )、有效 (4 3% )、无效 (18% ) ;显效率 (4 0 % ) ,有效率 (82 % )。结论　盐酸氟西汀对强迫症治疗有效 ,不良反应轻微 ,耐受性好 。Objective: To observe the clinical effectiveness and adverse effects of fluoxetine hydrochloride in treating patients with obsessive compulsive disorder (OCD). Methods: Fluoxetine Hydrochloride were administered to 63 patients with OCD. The reduction of Y BOCS was used for therapeutic effect evaluation and TESS for adverse effect assessment. Results: After 8 weeks treatment, total scores of Y BOCS, HAMD, HAMA and NIMH of 63 patients showed significant change compared with scores of pre treatment. The percentage of recovery, significant improvement, effectiveness, and no response was 12%, 27%, 43%, 18%, respectively, with 82% responsiveness rate. Conclusion: Fluoxetine hydrochloride shows therapeutic effect in OCD treatment with mild adverse effect and satisfactory tolerance, so may be beneficial for maintenance treatment.

关 键 词：盐酸氟西汀 强迫症 疗效 

分 类 号：R749.7[医药卫生—神经病学与精神病学]