EMMPRIN和MMP-2的表达与原发性肺癌临床病理学的关系  

Corrlations of EMMPRIN and MMP-2 Expression with Clinicopathological Features in Primary Lung Carcinoma

作　　者：高智[1] 蒋之[1] 王晓华[1] 

机构地区：[1]长沙市中心医院,湖南长沙410004

出　　处：《湖南师范大学学报（医学版）》2008年第2期34-37,共4页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:探讨原发性肺癌组织EMMPRIN和MMP-2蛋白的表达及其临床意义。方法:选取原发性肺癌患者116例,以正常肺组织38例作为对照,应用SP免疫组化方法检测EMMPRIN和MMP-2蛋白的表达。结果:原发性肺癌组织EMM-PRIN和MMP2蛋白的阳性表达率分别为71.6%(83/116)和69.8%(81/116),明显高于正常肺组织中的阳性表达率(5.3%和21.1%,P<0.01)。EMMPRIN和MMP2在中、低分化癌中的强阳性表达率高于高分化癌(P<0.05);在淋巴结转移组的强阳性率高于无淋巴结转移组(P<0.01);但二者的表达与肿瘤大小、组织学分型无明显关联。Spearman等级相关性检验分析表明原发性肺癌组织中EMMPRIN的表达和MMP2的表达之间呈正相关(r=0.729,P<0.01)。结论:EMMPRIN和MMP-2蛋白的过度表达与原发性肺癌的发生、浸润、转移有关,可作为新的原发性肺癌标记物用于联合检测,为临床治疗该肿瘤提供新的策略和方案。Objective To analyze the expressions of EMMPRIN and MMP-2 in human primary lung carcinoma,and to evaluate the clinical significance of these two markers in the progression of primary lung carcinoma.Methods 116 patients with primary lung carcinoma were examined for the expressions of EMMPRIN and MMP-2 by SP immunohistochemistry,and compared with 38 control cases of normal lung tissue.Results The positive expression rates of EMMPRIN and MMP2 in 116 patients with the primary lung carcinoma were 71.6%(83/116) a...

关 键 词：EMMPRIN MMP-2 临床病理学 原发性肺癌 

分 类 号：R734.2[医药卫生—肿瘤]