轻度认知功能障碍老年人和阿尔茨海默病关联性负变的比较  

Comparison of Contingent Negative Variation between Old Patients with Mild Cognitive Impairment and Alzheimer Disease

作　　者：宗文斌[1] 路英智[1] 白素云[1] 栾玉民[1] 马秀青[1] 田明萍[1] 

机构地区：[1]山东淄博市第五人民医院功能科,淄博255120

出　　处：《神经病学与神经康复学杂志》2005年第1期11-13,共3页Journal of Neurology and Neurorehabilitation

摘　　要：目的探讨轻度认知功能障碍老年人(MCI)和阿尔茨海默病(AD)的关联性负变(CNV)变异。方法应用美国 NicoletBravo 脑诱发电位仪,采用光和声成对刺激以及反应时间技术,记录了36例 MCI 患者的 CNV,并与45例健康老人(NC)和30例AD 患者的 CNV 进行比较。结果 MCI 和 AD 组波形不规则,CNV-Ⅱ型尤甚。MCI 组、AD 组及 NC 组在命令信号后负变化(PINV)、潜伏期 M_2、波幅 M_1及反应时间(RT)上差异有显著性(P<0.05～0.01)。与 NC 组相比,AD 组波幅降低和潜伏期延迟。MCI 组 PINV 出现率明显高于 NC 组。结论 CNV 是评定 MCI 患者和 AD 患者大脑综合功能的有效工具,在临床上值得进一步推广应用。Objective In order to investigate the contingent negative variation(CNV)between patients with mild cognitive impairment(MCI)and Alzheimer disease AD,the present study was initiated.Methods An event-relat- ed potentials CNV was recorded from 36 MCI patients using a Nicolet Bravo Instrument,and was compared with that of 30 patients with Alzheimer disease and 45 normally age-matched controls(NC).Results MCI and AD patients presented irregular CNV wavefrom,especially CNV-Ⅱtype.A significant difference of CNV among 3 subject groups was found with PINV,latency,amplitudes(M_2,M_1)and reaction time(RT)(P<0.05～0.01).Compared with NC group,AD group showed delayed M_2 latency and decreased M_1 amplitude(P<0.05-0.01).Compared with NC group,MCI group showed delayed PINV and inereased amplitude.Conclusion CNV is a useful tool for assessing the brain malfunction of MCI and AD,and its clinical applieation is recommended.

关 键 词：轻度认知功能障碍 阿尔茨海默病 关联性负变 命令信号后负变化 

分 类 号：R749.1[医药卫生—神经病学与精神病学]