失匹配负波在抑郁症患者中的应用  

Application of Mismatch Negativity(MMN)in Patients with Depression

作　　者：楼翡璎[1] 陈兴时[1] 张明岛[1] 梁建华[1] 陈欣伟[1] 

机构地区：[1]上海市精神卫生中心电生理室,上海200030

出　　处：《神经病学与神经康复学杂志》2005年第1期16-17,23,共3页Journal of Neurology and Neurorehabilitation

摘　　要：目的探讨失匹配负波(MMN)在抑郁症患者中的应用价值。方法应用美国 Nicolet Bravo 脑诱发电位仪对53例抑郁症和50例正常成人进行了 MMN 检测。结果与正常对照组相比,抑郁症患者 MMN 潜伏期后移(正常对照组:180.2±22.7ms.抑郁症组200.6±20.1 ms,t=4.8,P<0.01),波幅降低(正常对照组4.6±2.0μV,抑郁症组3.4±19μV,t=3.12.P<0.01)。结论 MMN 技术可反映抑郁症患者诱发脑电的自动加工过程。MMN 可作为抑郁症患者的临床应用检测指标。Objective To investigate the value of mismatch negativity in characteristics of patients with depres- sion.Methods The MMN was recorded from 53 depression patients and 50 normally age-matched controls,using an American Nicolet Bravo Instrument.Results Compared with normal control(NC)group,depression group prolonged latency(NC:180.2±22.7,depression:200.6±20.1ms,t=4.8,P<0.01)and decreased amplitude (NC:4.6±2.0μV,depression 3.4±1.9μV,t=3.12,P<0.01).Conclusion It is suggested that depression patients have abnormal brain automatic processing,and MMN may be useful index in evaluating depression brain dys- functions.

关 键 词：失匹配负波 抑郁症 正常对照组 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]