轻度认知功能障碍老年人和阿尔茨海默病患者听觉事件相关电位 P_(300)比较  

Comparison of P_(300) Between Patients with Mild Cognitive Impairment and Patients with Alzheimer Disease

作　　者：郭洪绪[1] 田明萍[1] 孙兆庆 马秀青[1] 李峰[1] 白素云[1] 

机构地区：[1]山东淄博市第五人民医院功能科,淄博255120

出　　处：《神经病学与神经康复学杂志》2005年第1期18-20,36,共4页Journal of Neurology and Neurorehabilitation

摘　　要：目的探讨轻度认知功能障碍老年人(MCI)和阿尔茨海默病(AD)在事件相关电位(ERP)P_(300)检测中的不同表现。方法收集符合 ICD-10诊断标准的36例 MCI 患者和30例 AD,并以45例健康老人作对照组(NC)。使用美国仪器以及"听觉靶—非靶刺激序列"为诱发事件,完成 P_(300)检测。结果(1)3组和 NC 组在靶潜伏期 Fz 脑区 N_2以及在靶波幅 F_z 恼区 P_2P_3和非靶波幅 Fz 脑区 P_2上均有显著差异(P<0.01)。(2)AD 主成分 N_2表现为延迟,与 NC 组和 MCI 组有极显著性差异(P<0.01)。(3)MCI 组和 AD 组靶波幅 P_3和非靶波幅 P_2均见降低,与 NC 组比较也有显著性差异(P<0.05～<0.01)。结论提示作为反映 MCI 和 AD 认知功能障碍的客观生理指标,P_(300)有可能作为 MCI 和 AD 辅助诊断的一个脑电生理学标志。P_(300)检查可作为老年精神科的必查项目。Objective To investigate the changes of event-related potentials P_(300)in patients with mild cognitive impairment and Alzheimer disease(AD).Methods An'oddball'paradigm was used to elicit the auditorv P_(300) from 36 patients diagnosed as having MCI according to ICD-10,30 patients with AD and 45 normally age-matched controls,by using a Nicolet.Bravo Instrument.Results A significant difference of ERP-P_(300)among 3 subject groups was found in both latencies(Fz/N_Z)and amplitudes(F_z/P_3,Fz/P_2)(P<0.01).Compared with NC and MCI groups,AD group showed prolonged latency(P<0.01)and decreased amplitude(P<0.01).Compared with NC groups,MCI and AD patients showed decreased P_3amplitude from target and P_2amplitude from nontarget(P< 0.05 or<0.01).Conclusion Auditory P_(300)ERP can serve as a physiological index in the accessory diagnosis of the cognitive disorder in MCI and AD.

关 键 词：轻度认知功能障碍老年人 阿尔茨海默病 事件相关电位P300 

分 类 号：R749.1[医药卫生—神经病学与精神病学]