脑干听觉反应在轻度认知功能障碍老年人和阿尔茨海默病中的应用  

Clinical Application of Auditory Brainstem Response in Patients with Mild Cognitive Impairment and Alzheimer Disease

作　　者：白素云[1] 宗文斌[1] 田明萍[1] 李峰[1] 郭洪绪[1] 栾玉民[1] 

机构地区：[1]山东淄博市第五人民医院功能科,淄博255120

出　　处：《神经病学与神经康复学杂志》2005年第1期21-23,共3页Journal of Neurology and Neurorehabilitation

摘　　要：目的探讨轻度认知功能障碍老年人(MCI)和阿尔茨海默病(AD)在脑干听觉反应(ABR)检测中的特点,为早期痴呆的诊断提供帮助。方法应用美国 Nicolet Bravo 脑电生理仪及 Click 短声刺激,测查36例 MCI 和30例阿尔茨海默病(AD)和45名健康老人(NC)的 ABR。结果 MCI 组、AD 组及 NC 组在绝对潜伏期波Ⅲ(Pz 脑区),绝对波幅波Ⅲ(Pz 脑区),波Ⅴ(Pz 脑区)上有差异极显著性(P<0.01)。与 NC 组和 MCI 组相比,绝对潜伏期波Ⅲ(Pz 脑区)上,AD 组延迟于 NC 组和 MCI 组(P<0.01)。波幅分析所见,绝对波幅波Ⅲ(Pz 脑区)和绝对波幅波Ⅴ(Pz 脑区)AD 组低于 NC 组和 MCI 组。MCI 组与 NC 组比较,差异有显著性(P<0.05)。结论 ABR 对临床辅助诊断 AD 和 MCI 有参考价值。Objective To investigate the characteristics of auditory brainstem response(ABR)in patients with mild cognitive impairment(MCI)and Alzheimer disease(AD).Methods The ABR was elicited from 36 MCI pa- tients,30 AD patients and 45 normally age-matched controls by presenting them with clicks using a Nicolet Bravo In- strument.Results A significant difference of ABR among 3 subject groups was found in both latencies(Pz/wave Ⅲ)and amplitudes(Pz/wave Ⅲ,Ⅴ)(P<0.01).Compared with NC group and MCI group,AD group showed pro- longed Ⅲ latency(from Pz)(P<0.01),and decreased wave Ⅲ(fron Pz)and wave Ⅴ(from Pz)amplitude(P< 0.01).Conclusion ABR is helpful to the diagnosis of AD and MCI.

关 键 词：轻度认知功能障碍 老年人 阿尔茨海默病 脑干听觉反应 

分 类 号：R749.1[医药卫生—神经病学与精神病学]