慢性酒精性周围神经病的电生理改变  

Electrophysiological Changes of Chronic Alcoholic Peripheral Neuropathy

作　　者：陆勤[1] 金嘉翔[1] 李威[1] 

机构地区：[1]上海第二医科大学附属第九人民医院神经内科,上海200011

出　　处：《神经病学与神经康复学杂志》2005年第1期24-27,共4页Journal of Neurology and Neurorehabilitation

摘　　要：目的探讨慢性酒精性周围神经病的电生理特点和诊断价值。方法检测36例慢性酒精中毒患者与35例正常人肌电图对照,统计分析。结果观察组中确诊为临床或亚临床周围神经病的共30例(83.33%)。观察组的正中神经、尺神经、胫后神经、腓总神经、腓肠、腓浅神经传导速度(NCV)及波幅明显低于正常对照组,感觉神经异常率高于运动神经,下肢异常率高于上肢。各神经传导速度与酒精摄入总量(TLDE)呈负相关。结论酒精对周围神经的毒性呈剂量依赖性。神经电生理检查能敏感地评价慢性酒精中毒患者的周围神经受损程度。Objective To study the electrophysiological character and the early diagnostic value of electroneu- rography in patients with chronic alcoholism.Methods A electrophysiological examination of 36 chronic alcoholics and 35 controls was made to assess the function of the peripheral nervous system.Results In 30 patients (83.33%),we observed the presence of clinical and/or subclinical neuropathy.Alcoholic patients exhibited re- duced nerve conduction velocities,compared with controls(P<0.01,of all nerve).The sensory nerve fibers were involved more severely than the motor nerve,and the lower limbs were involved more severely than the upper limbs. There was a significant negative correlation between nerve conduction velocity and total lifetime dose of ethanol. Conclusion Peripheral neuropathies are common among alcoholic patients.Alcohol appears to be toxic to peripheral nerves in a dose-dependent manner.And electroneurography is reliable and sensitive in the diagnosis of chronic alco- holic peripheral neuropathy.

关 键 词：酒精性周围神经病 神经传导速度 酒精摄入总量 

分 类 号：R747.9[医药卫生—神经病学与精神病学]