东菱克栓酶治疗急性缺血性卒中疗效评价  

Curative Effect of Batroxobin on Patients with Acute Ischemic Stroke

作　　者：陆朴莺[1] 支惠萍 高俊鹏 王俊 朱兴进[1] 朱扬[1] 

机构地区：[1]上海市第二人民医院神经内科,上海200011 [2]上海曙光医院神经内科,上海200021

出　　处：《神经病学与神经康复学杂志》2005年第3期137-139,共3页Journal of Neurology and Neurorehabilitation

摘　　要：目的探讨东菱克栓酶(东菱迪芙)对急性缺血性卒中患者神经功能缺损评分的改善作用以及对纤维蛋白原和血小板的影响。方法将110例急性脑卒中病人随机分为治疗组80例与对照组30例。治疗组采用东菱迪芙治疗,对照组采用血塞通注射液治疗。两组病人分别在入院时、3周后进行神经功能缺损评分及纤维蛋白原、血小板的评定与检测,并在3月后进行神经功能缺损评分的随访,进行比较。结果东菱迪芙组在3周时(P<0.05)及3月时(P<0.01)神经功能缺损评分改善方面均优于对照组,3月时两组的有效率分别为93.75%和76.67%,治疗组更佳(P<0.01),3周时治疗组在降低纤维蛋白原方面优于对照组(P<0.01),对血小板计数无影响(P>0.05)。结论东菱迪芙对急性缺血性卒中患者有确切治疗作用。Objective To investigate the curative effect of batroxobin on patients with acute ischemic stroke. Methods 110 patients who suffered from acute cerebral infarction were randomly divided into the experimental group with 80 patients and the control group with 30 patients.The experimental group was treated by batroxobin,while the control group was treated by Xuesaitong injection.The Modified Edinburgh-Scandinavian Stroke Scale(MESSS)and fibrinogen plus blood platelet were assessed and analyzed while those patients entering into the hospital 3 weeks later. Moreover,MESSS was assessed again 3 months later.All these data were compared between the two groups. Results The experimental group has a more dramatic improvement 3 weeks(P<0.05)and 3 months later(P< 0.01)when measured by MESSS.The effective rate of the two groups was 93.75% and 76.67% respectively when measured after 3 months(P<0.01),and the experimental group has a better curative effect.The reduction of fi- brinogen of the experimental group was more significant than that of the control group after 3-week-medication(P< 0.01).Both groups had no significant effect on the number of blood platelet.Conclusion Batroxobin has a sub- stantial curative effect on patients with acute ischemic stroke.

关 键 词：东菱克栓酶 急性缺血性卒中 纤维蛋白原 

分 类 号：R743.3[医药卫生—神经病学与精神病学]