大鼠脑电近似熵在局灶性脑梗死时的变化  

Changes of approximate entropy in rats during focal cerebral infarction

作　　者：欧阳铭文[1] 林春水[1] 秦再生[1] 古妙宁[1] 

机构地区：[1]南方医科大学南方医院麻醉科,广东广州510515

出　　处：《南方医科大学学报》2009年第7期1471-1473,共3页Journal of Southern Medical University

摘　　要：目的观察大鼠发生局灶性脑梗死时脑电(EEG)参数近似熵(ApEn)的变化,探讨ApEn是否对脑梗死的发生具有监测作用。方法选择SD大鼠24只,随机分为两组:脑梗死组(n=12),线栓法阻塞右侧大脑中动脉;对照组(n=12),行颈内动脉分离、结扎,不阻塞大脑中动脉。记录梗死组在梗死前(T0)、梗死即刻(T1)、梗死后5、15、30、60min(T2～5)时大鼠脑部缺血区域(C4)和正常区域(C3)的ApEn。按相同时间点记录对照组的ApEn。结果对照组各时间点C3、C4间及假手术后与基础值相比较均无统计学差异(P>0.05)。梗死组梗死前大鼠脑部C3、C4的EEG参数ApEn基本相同。梗死后,脑部C3、C4的ApEn较梗死前均升高,C4低于C3(P<0.05);ApEn随时间进行性下降;梗死后30min时,C4的ApEn已低于梗死前的值(P<0.05)。对照组C3、C4区域各个时间点的ApEn均无明显差异。两组在梗死前和假手术时的ApEn比较无明显差异。结论ApEn可对大鼠脑部出现的单侧局灶性梗死进行监测,可能对梗死后的脑缺血程度有一定的判定作用。Objective To investigate the changes of EEG approximate entropy(ApEn) in rats during focal cerebral infarction.Methods Twenty-four Sparague-Dawley(SD) rats were randomly divided into infarction group(n=12) with middle cerebral artery occlusion and sham-operated group(n=12).The EEG data(ApEn) was recorded in the bilateral areas(C3,C4) of the rats with focal cerebral infarction before the infarction and immediately and at 5,15,30,and 60 min after the infarction.The same measurement was carried out in the sham...

关 键 词：局灶性脑梗死 脑电描记术 近似熵 

分 类 号：R743.33[医药卫生—神经病学与精神病学]