阿霉素免疫毫微粒对多药耐药肝癌的体内杀伤作用  

Effect of immunonanoparticles loaded with adriamycin on multidrug-resistant liver cancer in nude mice

作　　者：阚和平[1] 王宇[1] 谭永法[1] 周杰[1] 

机构地区：[1]南方医科大学南方医院肝胆外科,广东广州510515

出　　处：《南方医科大学学报》2009年第8期1617-1619,共3页Journal of Southern Medical University

基　　金：广东省自然科学基金(04020454)

摘　　要：目的探讨阿霉素免疫毫微粒对多药耐药(MDR)肝癌的体内杀伤作用及其可能的机制。方法用人肝癌细胞株耐阿霉素亚株(SMMC-7721/ADM)制成肝癌裸鼠模型,分别使用阿霉素免疫毫微粒、阿霉素毫微粒及阿霉素,检测三者的肿瘤抑制率;同时检测三者在肿瘤组织中的药物浓度。结果阿霉素免疫毫微粒有比普通阿霉素毫微粒及阿霉素更强的体内逆转MDR的功能;阿霉素免疫毫微粒比阿霉素毫微粒及阿霉素在肿瘤中的药物浓度明显高。结论免疫毫微粒有体内逆转MDR的功能,其可能机制是免疫毫微粒在体内可与肿瘤细胞紧密结合,所载药物释放后形成肿瘤组织内有较高的药物浓度。Objective To observe the effect of the immunonanoparticles loaded with adriamycin in reversing multidrug resistance (MDR) in liver cancer in a nude mouse model and explore the possible mechanisms. Methods The cytotoxicity of adriamycin, adriamycin-loaded nanoparticles, and adriamycin-loaded immunonanoparticles was assessed in a nude mouse model bearing implant tumors of adriamycin-resistant hepatoma cell line SMMC-7721/ADM. The concentration of adriamycin in the tumor tissue was determined. Results Adriamyc...

关 键 词：免疫毫微粒 多药耐药 肝肿瘤 阿霉素 

分 类 号：R735.7[医药卫生—肿瘤]