N-CWS灌胃对小鼠移植性肿瘤及免疫功能的影响  

Effect of Nocardia rubra Cell Wall Skeleton(N-CWS) on Transplanted Tumor and Immunological Function in Mice Given Through Oral Administration

作　　者：张祝兰[1] 唐文力[1] 杨煌建[1] 王娟[1] 洪金基[1] 

机构地区：[1]福建省微生物研究所,福州350007

出　　处：《天然产物研究与开发》2010年第2期228-231,共4页Natural Product Research and Development

基　　金：福建省自然科学基金项目(2007J0248)

摘　　要：为了考察红色诺卡氏菌细胞壁骨架(Nocardia rubra cell wall skeleton,N-CWS)灌胃给药对小鼠的体内抑瘤效应及其免疫调节作用,采用小鼠肉瘤S180的移植性肿瘤模型,检测N-CWS灌胃给药的抑瘤活性;同时观察N-CWS体内细胞毒作用和对正常小鼠的毒性、免疫器官重量、巨噬细胞(MΦ)吞噬功能及脾淋巴细胞转化的影响。结果显示,小鼠灌服N-CWS的LD50>1.2g/kg;N-CWS200、400、800mg/kg剂量灌胃小鼠对S180有明显的抑制作用,其抑瘤率分别为63.33%、71.11%、64.88%;与对照组比较,N-CWS可增加免疫器官重量和提升外周血白细胞数量、能明显提高小鼠MΦ的吞噬活性及显著提高淋巴细胞转化率(P<0.05),同时N-CWS激活了的MΦ对肿瘤细胞的细胞毒效应亦明显增强(P<0.05)。因此N-CWS适用于口服给药,对小鼠移植性肿瘤有明显的抑制作用,其抗肿瘤作用可能与增强机体免疫功能有关。It was studied the effect of Nocardia rubra cell wall skeleton(N-CWS)on transplanted tumor and immunological function in mice given in oral administration.Transplanted tumor model of sarcoma 180 in mice was used to evaluate the antitumor effect of N-CWS.Meanwhile the immune organ weights,the phagocytosis of peritoneal macrophage and the lymphocyte transformation were determined in normal mice.After oral administration of N-CWS 200,400,800 mg/kg to mice,the inhibition rates on sarcoma 180 were 63.33%,71.11%,...

关 键 词：红色诺卡氏菌细胞壁骨架 抗肿瘤 免疫调节 给药途径 

分 类 号：R73-3[医药卫生—肿瘤]