金耳菌丝体多糖对实验性2型糖尿病大鼠的降血糖作用研究  

Hypoglycemic Activity of Polysaccharides Extracted from Tremella aurantialba Mycelia in Experimental Type 2 Diabetic Rats

作　　者：张雯[1] 赵旌旌[1] 王捷思[1] 朱兴磊[1] 张敏[1] 瞿伟菁[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062

出　　处：《天然产物研究与开发》2010年第1期49-53,共5页Natural Product Research and Development

基　　金：上海市经济委员会科研项目(07X12-029)

摘　　要：本文研究了金耳菌丝体多糖(TMP)对实验性2型糖尿病大鼠血糖、血脂、胰岛素敏感性和抗氧化能力的影响。采用烟酰胺,链脲佐菌素和高脂饲料诱导2型糖尿病大鼠模型,以50和100mg/(kg.d)剂量的TMP连续灌胃48d,监测血糖,测定血清胰岛素、体重、脂代谢及抗氧化系统部分相关指标,并进行口服糖耐量实验。结果显示,TMP可明显降低2型糖尿病大鼠的血清葡萄糖、总胆固醇、甘油三酯和丙二醛水平,并极显著提高受试模型鼠的胰岛素敏感指数,血清超氧化物歧化酶活性和肝脏过氧化氢酶活性。此外,TMP能显著降低糖耐量实验中糖负荷后120min时糖尿病大鼠的血糖含量。上述结果表明TMP可有效降低实验性2型糖尿病大鼠的血糖水平,纠正脂代谢紊乱,改善胰岛素抵抗,增强抗氧化能力。The present study was designed to evaluate the effects of crude polysaccharides extracted from Tremella aurantialba mycelia(TMP)on serum glucose,insulin sensitivity,lipid profiles and antioxidant parameters in nicotinamide and streptozotocin(STZ)-induced type 2-like diabetic rats.Type 2-like diabetes in rat was induced by nicotinamide,STZ and high fat diet.50 and 100 mg/(kg·d)TMP were fed by intragastric administration to diabetic rats once a day lasting for 48 days.In this study,we focused on measuring the...

关 键 词：金耳菌丝体多糖(TMP) 胰岛素敏感性 2型糖尿病大鼠 降血糖作用 降血脂作用 

分 类 号：R285.5[医药卫生—中药学]