Regulation of apoptotic signal transduction pathways by the heat shock proteins  

作　　者：LI Zhengyu1, ZHAO Xia1 & WEI Yuquan2 1. Department of Gynecology and Obstetrics, West China Second Hospital of Sichuan University, Chengdu 610041, China 2. Key Laboratory of Biotherapy of Human Diseases of Ministry of Education, West China Hospital of Sichuan university, Chengdu 610041, China 

出　　处：《Science China(Life Sciences)》2004年第2期107-114,共8页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.30070835&30070294);National 863 Project.

摘　　要：The study about apoptotic signal transductions has become a project to reveal the molecular mechanisms of apoptosis. Heat shock proteins (hsps), which play an important role in cell growth and apoptosis, have attracted great attentions. A lot of researches have showed there is a hsps superfamily including hsp90, hsp70, hsp60 and hsp27, etc., which regulates the bio-logical behaviors of cells, particularly apoptotic signal transduction in Fas pathway, JNK/SAPK pathway and caspases pathway at different levels, partly by the function of molecular chaperone.The study about apoptotic signal transductions has become a project to reveal the molecular mechanisms of apoptosis. Heat shock proteins (hsps), which play an important role in cell growth and apoptosis, have attracted great attentions. A lot of researches have showed there is a hsps superfamily including hsp90, hsp70, hsp60 and hsp27, etc., which regulates the bio-logical behaviors of cells, particularly apoptotic signal transduction in Fas pathway, JNK/SAPK pathway and caspases pathway at different levels, partly by the function of molecular chaperone.

关 键 词：heat shock protein  APOPTOTIC signal transduction  MOLECULAR chaperone  caspases. 

分 类 号：Q51[生物学—生物化学]