^(177)Lu^m的分离纯化和^(177)Lu^m-EDTMP的制备  

Separation, Purification of^(177)Lu^m and Preparation of^(177)Lu^m-EDTMP

作　　者：陈大明[1] 桥本和幸 

机构地区：[1]中国原子能科学研究院同位素研究所,北京102413 [2]日本原子力研究所研究堆部茨城

出　　处：《核化学与放射化学》2004年第2期84-87,共4页Journal of Nuclear and Radiochemistry

摘　　要：介绍了一种新的177Lum分离纯化方法:堆照天然Lu2O3靶,经过长时间冷却后,配制成0.1mol/L的HCl溶液并注入NH+4型阳离子交换柱,用0.12mol/Lα 羟基异丁酸洗脱177Lum及其他放射性核素,将含有177Lum的洗脱液通过H+型阳离子交换柱,用0.1mol/LHCl溶液除去α 羟基异丁酸,又用6mol/L的HCl洗脱、蒸干后得到177Lum的0.1mol/LHCl溶液。最后得到177Lum的放射性活度为18.17MBq,Lu2O3比活度为0.624MBq/mg,放射性纯度大于99%,产率为97%。用得到的177Lum对EDTMP进行标记,建立了测定177Lum EDTMP标记率的快速展开体系。当ρ(EDTMP)>0.15mg/mL,ρ(Lu2O3)=0.047mg/mL,pH=5～11,在室温下反应5min时,177Lum EDTMP的标记率大于97%。表明177Lum EDTMP可用于潜在骨肿瘤治疗剂177Lu EDTMP的进一步研究。The new separation and purification method for^(177)Lu^m is investigated: the solution of 30 mg natural Lu_2O_3 target irradiated with thermal neutron for 26 d and decayed for 11 months is passed through a NH^+_4 type cation exchange column,^(177)Lu^m and other radionuclides are separated with 0.12 mol/L α-hydroxyisobytyric acid eluent. The^(177)Lu^m is purified from the 0.12 mol/L α-hydroxyisobytyric acid by elution 0.1 mol/L HCl from a H^+ type cation exchange column. The labeling of EDTMP with^(177)Lu^m is obtained. The results show radioactivity of purified^(177)Lu^m is 18.17 MBq, special (activity) 0.624 MBq/mg Lu_2O_3, radioactive purity over 99%, the yield is 97%. The fast paper chromatography of^(177)Lu^m-EDTMP is established, the labeling efficiency of^(177)Lu^m-EDTMP is more than 97% with the optimized labeling condition: ρ(EDTMP)>0.15 mg/mL, ρ(Lu_2O_3)=0.047 mg/mL, pH=5～10, the room temperature, 5 min.^(177)Lu^m-EDTMP can be used in the further study of^(177)Lu^m-(EDTMP), which a potential therapeutic agent for bone metastases.

关 键 词：镥177 分离 纯化 乙二胺四亚甲基膦酸 骨肿瘤 治疗剂 

分 类 号：R738.1[医药卫生—肿瘤] R730.53[医药卫生—临床医学]