杨树皮不饱和脂肪酸对实验性高脂血症大鼠血脂的影响  

Effect of poplar skin monounsaturated fatty acid on the lipid profile of atherosclerosis in rats

作　　者：孟群[1] 汪岱迪[1] 金卫红[1] 

机构地区：[1]江苏省药品检验所,南京210008

出　　处：《药品评价》2004年第5期364-365,共2页Drug Evaluation

摘　　要：目的评价杨树皮不饱和脂肪酸对实验性高脂血症大鼠血脂的影响。方法将雄性大鼠60只,随机分成6组,即:基础饲料对照组(1),病理模型组(2),杨树皮不饱和脂肪酸高剂量组(3)、中剂量组(4)、低剂量组(5)及烟酸阳性对照组(6),连续给药15d,末次给药后14h分离血清,测定血清中TC、TG、LDL-C、HDL-C的浓度。结果杨树皮不饱和脂肪酸能显著降低实验性高脂血症大鼠的血清总胆固醇(TC)、甘油三脂(TG)和低密度脂蛋白的胆固醇(LDL-C)水平,而对血清中高密度脂蛋白的胆固醇(HDL-C)含量有升高作用。结论杨树皮不饱和脂肪酸具有调节血清TC、TG、HDL-C的作用。Objective To observe the effect of poplar skin monounsaturated fatty acid(PSMFA) on the lipid profile of atherosclerosis in rats. Methods Sixty male rats were randomized into six groups with 10 rats in each groups. They are the control group(1), the cholesterol group(2), the PSMFA high dose group(3), the PSMFA medium dose group(4), the PSMFA low dose group(5) and the Nicotinic Acid group(6). All the rats were fed for 15 days. Blood samples were drawn before and after the experiment. Total cholesterol (TC), low density lipoprotein cholesterol(LDL-C), triglyceride(TG),and high density lipoprotein cholesterol(HDL-C) were measured enzymatically. Results Compared with the group(2),the TC, the TG and the LDL-C were lowered markedly by PSMFA, the HDL-C were improved markedly by PSMFA. Conclusion PSMFA has effect on the lipid profile by reducing the TC, the TG , the LDL-C and improving the HDL-C.

关 键 词：杨树皮不饱和脂肪酸 降血脂 实验性高脂血症大鼠 

分 类 号：R96[医药卫生—药理学]