The Nongenomic Effects of Progesterone in Repressing iNOS Activation through P38MAPK Pathways in Gonococci-Infected Polymorphonuclear Leukocytes and the Clinical Significance  

作　　者：陈嵘祎 涂亚庭 林加西 佘惟槟 李娟 吴志洪 许莉 陈宏翔 

机构地区：[1]Department of Dermatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology [2]Guangdong Medical College

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2010年第1期119-125,共7页华中科技大学学报（医学英德文版）

基　　金：supported by the Young Scientists Fund Program of National Natural Science Fund Program from National Natural Sciences Foundation of China(No.30371293);Medical Research Foundation of Guangdong Province of China(No.B2009193)

摘　　要：Progesterone has nongenomic effects on inducible nitric oxide synthase(iNOS),which is mediated by mitogen activated protein kinase(MAPK)pathways.This effect is supposed to have some potential association with asymptomatic gonococcal infections in women by immunological depression.In this study,polymorphonuclear leukocytes(PMNs)challenged by gonococci were used to study the nongenomic effects of progesterone.The activation of iNOS was assessed by measuring [3H] L-arginine converses to [3H] L-citrulline,and t...Progesterone has nongenomic effects on inducible nitric oxide synthase(iNOS),which is mediated by mitogen activated protein kinase(MAPK)pathways.This effect is supposed to have some potential association with asymptomatic gonococcal infections in women by immunological depression.In this study,polymorphonuclear leukocytes(PMNs)challenged by gonococci were used to study the nongenomic effects of progesterone.The activation of iNOS was assessed by measuring [3H] L-arginine converses to [3H] L-citrulline,and t...

关 键 词：asymptomatic infection gonococcus inducible nitric oxide synthase nongenomic effects PROGESTERONE 

分 类 号：R759.2[医药卫生—皮肤病学与性病学]