甲磺酸瑞波西汀合成工艺改进研究  

Study on synthesis of reboxetine mesylate

作　　者：李倩[1] 赵世明[2] 孙有光[1] 尚嘉鹏[2] 

机构地区：[1]天津理工大学化学化工学院,天津300384 [2]天津药物研究院化学制药研究部,天津300193

出　　处：《天津理工大学学报》2010年第2期70-73,共4页Journal of Tianjin University of Technology

摘　　要：针对甲磺酸瑞波西汀合成工艺中存在的缺点与不足进行了优化和改进,以反式肉桂醇为原料,依次经过环氧化,加成,酯化,氨化,酰胺化,合环,还原反应得到成品,改进后,简化了工艺,减少了反应时间,降低了成本,减少了有毒试剂的使用,提高了生产收率,总收率达20.7%,更适于大规模工业化生产.For the shortcomings and deficiencies of synthesis of reboxetine mesylate,the method has been optimized and improved,taking cinnamyl alcohol as the starting raw material,followed by epoxidation,addition,esterification,amination,cyclization,restore then get the final product,reduced use of toxic reagents and improve the production yield,the total yield of 20.7%,more suitable for large-scale industrial production.

关 键 词：肉桂醇 合成 优化 

分 类 号：TQ463.2[化学工程—制药化工]