Solitary concomitant endocrine tumor and ductal adenocarcinoma of pancreas  

作　　者：Shih-Tang Yan Chang-Kuo Wei Chih-Wen Lin Chih-En Tseng 

机构地区：[1]Department of Endocrinology and Metabolism,Buddhist Dalin Tzu Chi General Hospital,Chiayi 622,Taiwan,China [2]Department of General Surgery,Buddhist Dalin Tzu Chi General Hospital,Chiayi 622,Taiwan,China [3]Department of Medical Imaging,Buddhist Dalin Tzu Chi General Hospital,Chiayi 622,Taiwan,China [4]Department of Anatomic Pathology,Buddhist Dalin Tzu Chi General Hospital,Chiayi 622,Taiwan,China [5]School of Medicine,Tzu Chi University,Hualien 97004,Taiwan,China

出　　处：《World Journal of Gastroenterology》2010年第21期2692-2697,共6页世界胃肠病学杂志（英文版）

基　　金：Supported by Buddhist Dalin Tzu Chi General Hospital

摘　　要：Pancreatic tumors with combined exocrine and endocrine features are rare.Most reported cases are classified as mixed exocrine and endocrine carcinoma of the pancreas.We report the first case of solitary concomitant endocrine tumor and ductal adenocarcinoma of the pancreas.A 58-year-old patient was admitted for uncontrolled diabetes mellitus and body weight loss.The tumor was fortuitously discovered in the pancreatic tail after a tumor survey panel.Grossly,the solitary tumor had a central fibrous band that clearly divided it into two parts.On microscopic examination,the tumor contained both endocrine and exocrine components distinctly separated by the central fibrous band.The exocrine part showed a poorly-differentiated adenocarcinoma.The endocrine part was strongly immunoreactive to chromogranin,synaptophysin and glucagon.We reviewed the literature on pancreatic tumors with combined exocrine and endocrine features.A simple classification for this group of neoplasms is suggested,including five types:amphicrine,mixed,collision,solitary concomitant and multiple concomitant.Pancreatic tumors with combined exocrine and endocrine features are rare.Most reported cases are classified as mixed exocrine and endocrine carcinoma of the pancreas.We report the first case of solitary concomitant endocrine tumor and ductal adenocarcinoma of the pancreas.A 58-year-old patient was admitted for uncontrolled diabetes mellitus and body weight loss.The tumor was fortuitously discovered in the pancreatic tail after a tumor survey panel.Grossly,the solitary tumor had a central fibrous band that c...

关 键 词：PANCREAS Concomitant tumor Collision tumor Mixed tumor GLUCAGONOMA 

分 类 号：R735.9[医药卫生—肿瘤]