Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents  

作　　者：He, Li Qin Liu, Jing Yin, Deng Ke Zhang, Yi Hua Wang, Xiao Shan 

机构地区：[1]China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China [2]Anhui Univ Tradit Chinese Med, Anhui Key Lab Modernized Chinese Mat Med, Hefei 230031, Anhui, Peoples R China

出　　处：《Chinese Chemical Letters》2010年第4期381-384,共4页中国化学快报（英文版）

摘　　要：A series of furoxan-based nitric oxide-releasing matrine derivatives(10a-f) were synthesized.The biological evaluation showed that compounds 10a,10b,10e and 10f had stronger cytotoxic activities than 5-fluorouracil against human hepatoma cells(HepG2) in vitro.

关 键 词：MATRINE FUROXAN Anti-tumor activity HEPG2 

分 类 号：R96[医药卫生—药理学]