Enantioselective addition of diethylzinc to aryl aldehydes catalyzed by 1,2,3,4-tetrahydroisoquinoline β-amino alcohol  

作　　者：Geng Xu Zhan Zhu Liu 

机构地区：[a] Key Laboratory of Bioactive Substances Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education. Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China

出　　处：《Chinese Chemical Letters》2010年第3期309-311,共3页中国化学快报（英文版）

摘　　要：A highly effective,new chiral 1,2,3,4-tetrahydroisoquinoline catalyst 1 for the diethylzinc addition to aryl aldehydes has been investigated.Using 10 mol%of this chiral catalyst,secondary alcohols can be obtained in up to 87%yield and 99.5%ee under mild conditions.

关 键 词：β-Amino alcohol TETRAHYDROISOQUINOLINE DIETHYLZINC Asymmetric addition 

分 类 号：O643.32[理学—物理化学]