TETRAHYDROISOQUINOLINE

作品数：17被引量：15H指数：2
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相关作者：薛玲静更多>>
相关机构：中国药科大学河南工业大学更多>>
相关期刊：《Science China Chemistry》《Open Journal of Medicinal Chemistry》《Chemical Research in Chinese Universities》《Genes & Diseases》更多>>
相关基金：国家自然科学基金天津市自然科学基金中国博士后科学基金高等学校学科创新引智计划更多>>
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Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis
《Acta Pharmaceutica Sinica B》2023年第3期1318-1325,共8页Ning Shao Xueyang Ma Ying-Ying Zhang Donghui Yang Ming Ma Gong-Li Tang 
supported by the National Natural Science Foundation of China(Nos.31930002,21621002,21877002,81991525,82273829 and 22077007);the key project at central government level:the ability establishment of sustainable use for valuable Chinese medicine resources(2060302-2201-17).
Dihydrofolate reductase(DHFR),a housekeeping enzyme in primary metabolism,has been extensively studied as a model of acid-base catalysis and a clinic drug target.Herein,we investigated the enzymology of a DHFR-like pr...
关键词：Catalytic mechanism Crystal structure Dihydrofolate reductase(DHFR) Hemiaminal pharmacophoreSacH Safracin biosynthesis Self-resistance Tetrahydroisoquinoline(THIQ)alkaloids 
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 proteineprotein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells被引量：2
《Genes & Diseases》2022年第6期1674-1688,共15页Shasha Cheng Guan-Jun Yang Wanhe Wang Dik-Lung Ma Chung-Hang Leung 
This work was supported by the Health and Medical Research Fund(No.HMRF/14150561);the National Natural Science Foundation of China(No.201575121 and 21775131);the Hong Kong Baptist University Century Club Sponsorship Scheme 2020,Teaching Development Fund(No.TDG/1920/02);the Science and Technology Development Fund,Macao SAR,China(File no.0072/2018/A2 and 0007/2020/A1);SKLQRCM(UM)-2020-2022;the University of Macao,China(MYRG2019e00002eICMS).
Triple-negative breast cancer(TNBC)is a highly aggressive and metastasizing cancer that has the worst prognosis out of all breast cancer subtypes.The epithelial emesenchymal transition(EMT)and cancer stem cells(CSCs)h...
关键词：Cancer stem cells CDK9-cyclin T1 Epithelial mesenchymal transition Proteineprotein interaction(PPI) Triple-negative breast cancer(TNBC) 
Efficient CO_(2) electroreduction coupled with semi-dehydrogenation of tetrahydroisoquinoline by MOFs modified electrodes
《Journal of Energy Chemistry》2021年第12期328-335,I0008,共9页Zi-Hao Zhu Ze-Long Liang Sheng-Li Hou Yao Xie Yue Ma Yan Zhang Bin Zhao 
supported by the National Nature Science Foundation of China (21625103 and 21971125);the China Postdoctoral Science Foundation (2019M660978 and 2020T130319);the 111 Project (B12015)。
Electroreduction of CO_(2) into formate catalyzed by metal-organic frameworks(MOFs) is a promising avenue to promote the carbon cycle,but the oxygen evolution reaction(OER) process in anode usually limited the reactio...
关键词：MOFS Carbon dioxide electroreduction Electrocatalysis Semi-dehydrogenation Electrodeposition 
Synthesis of tetrahydroisoquinolines through TiCl4-mediated cyclization and Et3SiH reduction被引量：1
《Chinese Chemical Letters》2020年第3期729-732,共4页Zeyu Shi Qiong Xiao Dali Yin 
financial support from Drug Innovation Major Project(No.2018ZX09711-001-005);CAMS Collaborative Innovation Project(No.2017-I2M-2-004)。
A versatile and efficient telescoped reaction sequence for the synthesis of tetrahydroisoquinolines(THIQs)is reported that uses TiCl4 to promote cyclization of a benzylaminoacetal derivative and Et3SiH for reduction o...
关键词：TETRAHYDROISOQUINOLINE TICL4 CYCLIZATION Et3SiH Telescoped REACTION 
Integrating photocatalytic reduction of CO2 with selective oxidation of tetrahydroisoquinoline over InP–In2O3 Z-scheme p-n junction被引量：3
《Science China Chemistry》2020年第1期28-34,共7页Bohang Zhao Yi Huang Dali Liu Yifu Yu Bin Zhang 
supported by the National Natural Science Foundation of China(21422104);the Natural Science Foundation of Tianjin City(17JCJQJC44700,16JCZDJC30600)
The development of a facile strategy to construct stable hierarchal porous heterogeneous photocatalysts remains a great challenge for efficient CO2 reduction.Additionally,hole-trapping sacrificial agents(e.g.,triethan...
关键词：CO2 reduction DEHYDROGENATION photocatalysis Z-scheme TETRAHYDROISOQUINOLINE 
Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer被引量：4
《Acta Pharmaceutica Sinica B》2016年第1期93-99,共7页Danqi Chen Aijun Shen Guanghua Fang Hongchun Liu Minmin Zhang Shuai Tang Bing Xiong Lanping Ma Meiyu Geng Jingkang Shen 
supported financially by the National Science & Technology Major Project ‘Key New Drug Creation and Manufacturing Program’ of China(Grant No.2014ZX09507002);the National Marine ‘863’ Project(No.2013AA092902)
Histone acetylation is a critical process in the regulation of chromatin structure and gene expression.Histone deacetylases(HDACs)remove the acetyl group,leading to chromatin condensation and transcriptional repressio...
关键词：HISTONE DEACETYLASES INHIBITOR ANTICANCER TETRAHYDROISOQUINOLINE Structure–activity relationship 
Tungstophosphoric acid catalyzed synthesis of N-sulfonyl-1,2,3,4-tetrahydroisoquinoline analogs被引量：2
《Chinese Chemical Letters》2013年第10期941-944,共4页Ratchanok Pingaew Supaluk Prachayasittikul Somsak Ruchirawat Virapong Prachayasittikul 
the research grant from Srinakharinwirot University(B.E.2555);supported by Offce of the Higher Education Commission;Mahidol University under the National Research Universities Initiative
An operationally simple and eco-friendly protocol has been developed for the synthesis of N-sulfonyl- 1,2,3,4-tetrahydroisoquinolines 3 using the modified Pictet-Spengler reaction of N-sulfonylphenylethy- lamines 1 an...
关键词：Pictet-Spengler reaction Isoquinoline Heteropoly acid Sulfonamide 
1-Chloromethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid amide, a derivative of tetrahydroisoquinoline, induces granulocytic differentiation of the human leukemic HL-60 cells via G0/G1 phase arrest
《Health》2013年第5期1-7,共7页Sung-Min Ju Hyun-Ock Pae Won-Sin Kim Chai-Ho Lee Byung-Hun Jeon 
Tetrahydroisoquinolines are known to have various biological effects, including antitumor activity. This study investigated the effect of 1-chloromethyl-6, 7-dimethoxy-3, 4-dihydro-1H-isoquinoline-2-sulfonic acid amid...
关键词：Differentiation G0/G1 PHASE ARREST HL-60 Cells TETRAHYDROISOQUINOLINES P27Kip1 
Flexible Synthesis of Enantiomeric and Racemic 3-Hydroxymethyl-1,2,3,4-tetrahydroisoquinolines via Bischler-Napieralski Reaction
《Chemical Research in Chinese Universities》2012年第5期843-846,共4页KANG Chuan-qing DU Zhi-jun WANG Lan-lan CHEN Yu QIU Xue-peng GUO Hai-quan GAO Lian-xun 
With methyl ester of N-acylated L-3-（3,4-dihydroxyphenyl）alanine（L-DOPA） as starting material, racemic derivatives of 3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline were obtained with cyclization by Bischler-Napie...
关键词：1 2 3 4-Tetrahydroisoquinoline Bischler-Napieralski reaction Racemerization 
Synthesis and Evaluation of Anticonvulsant Activity of 6,8-Dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline in PTZ-Induced Seizure Model in Mice
《Open Journal of Medicinal Chemistry》2012年第3期72-77,共6页Yothawathorn Pariyawongsakul Chamnan Patarapanich Chantana Boonyarat Ploenthip Puthongking 
This study we describe the synthesis of a novel structure of anticonvulsant agent as 6,8-dimethoxy-3-methyl-1,2,3,4- tetrahydroisoquinoline by using GYKI52466, which was the potent anticonvulsant agent, as the lead mo...
关键词：ANTICONVULSANT PENTYLENETETRAZOLE TETRAHYDROISOQUINOLINE 
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