云南高校图书馆联盟文献共享服务平台- TETRAHYDROISOQUINOLINES

TETRAHYDROISOQUINOLINES: 作品数：13被引量：10H指数：2; 导出分析报告; 相关领域：理学化学工程更多>>; 相关机构：海南师范大学更多>>; 相关期刊：《American Journal of Analytical Chemistry》《Science China Chemistry》《Asian Pacific Journal of Tropical Biomedicine》《Chinese Journal of Chemistry》更多>>; 相关基金：国家自然科学基金更多>>

Quick assembly of 1-alkylidenyl-tetrahydroisoquinolines via a Catellani reaction/NBS-mediated cyclization sequence and synthetic applications: 《Science China Chemistry》2023年第11期3136-3140,共5页Shihu Jia Miao Bai Siwei Zhou Ruiqing Sheng Hong-Gang Cheng Qianghui Zhou; supported by the National Natural Science Foundation of China(21801193,21871213 and 22071189);the Natural Science Foundation of Jiangsu Province(BK20210119,Hong-Gang Cheng);the Fundamental Research Funds for the Central Universities(2042021kf0214 and 2042020kf0039);the Start-up Funding from Wuhan University。; We herein disclose a modular synthesis of 1-bromomethylene-THIQs involving a Catellani reaction of aryl iodides,aziridines,and terminal alkynes followed by an N-bromosuccinimide(NBS)-mediated cyclization.This approach...; 关键词：1-bromomethylene-THIQ Catellani reaction (±)-cularine 8-oxopseudopalmatine dactyllactone A

Synthesis of tetrahydroisoquinolines through TiCl4-mediated cyclization and Et3SiH reduction被引量：1: 《Chinese Chemical Letters》2020年第3期729-732,共4页Zeyu Shi Qiong Xiao Dali Yin; financial support from Drug Innovation Major Project(No.2018ZX09711-001-005);CAMS Collaborative Innovation Project(No.2017-I2M-2-004)。; A versatile and efficient telescoped reaction sequence for the synthesis of tetrahydroisoquinolines(THIQs)is reported that uses TiCl4 to promote cyclization of a benzylaminoacetal derivative and Et3SiH for reduction o...; 关键词：TETRAHYDROISOQUINOLINE TICL4 CYCLIZATION Et3SiH Telescoped REACTION

NHC-catalyzed Redox-Neutral Aza-Benzoin Reaction of Aldehydes with Tetrahydroisoquinolines: 《Chinese Journal of Chemistry》2020年第2期135-138,共4页Di Jiang Zijun Wu Jian Wang; the National Natural Science Foundation of China(Nos.21672121 and 21871160);the"Thousand Plan"Youth Program of China,Tsinghua University,the Bayer Investigator Fellowship,and the Fellowship of Tsinghua-Peking Centre for Life Sciences(CLS).; Summary of main observation and conclusion Tetrahydroisoquinoline derivatives are useful synthetic intermediates,which play an important role in the preparation of natural products,pharmaceuticals and other materials....; 关键词：materials. QUINOLINE ALDEHYDES

Dual Stereocontrol for Enantioselective Hydrogenation of Dihydroisoquinolines Induced by Tuning the Amount of N-Brornosuccinirnide被引量：1: 《Chinese Journal of Chemistry》2018年第2期139-142,共4页Yue Ji Jie Wang Muwang Chen Lei Shi Yonggui Zhou; We are grateful for the financial support from the National Natural Science Foundation of China （Nos. 21472188, 21690074）,the State Key Laboratory of Fine Chemicals （No. KF1503） and the Youth Innovation Promotion Association of Chinese Academy of Sciences （No, 2014167）.; An efficient dual stereocontrot in iridium-catalyzed hydrogenation of 1-substituted 3,4-dihydroisoquinolines was realized by tuning the amount of N-bromosuccinimide using chiral ligand of single configuration, providi...; 关键词：reversal of enantioselectivity hydrogenation N-BROMOSUCCINIMIDE 1 2 3 4-tetrahydroisoquinolines

C–H allylation of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with iodide catalysis被引量：3: 《Science China Chemistry》2016年第2期171-174,共4页Zhujia Feng Tingting Zeng Jun Xuan Yunhang Liu Liangqiu Lu Wen-Jing Xiao; supported by the National Natural Science Foundation of China(21232003;21202053;21572074);the Foundation for the Author of National Excellent Doctoral Dissertation of China(201422);Outstanding Youth Funding in Hubei Province(2015CFA033); A dual catalytic system, combing visible light photoredox catalysis and iodide catalysis, has been developed for the functionalization of inert C–H bonds. By doing so, radical allylation reactions of N-aryl-tetrahydr...; 关键词：visible light photocatalysis iodide catalysis ALLYLATION TETRAHYDROISOQUINOLINES

Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer被引量：4: 《Acta Pharmaceutica Sinica B》2016年第1期93-99,共7页Danqi Chen Aijun Shen Guanghua Fang Hongchun Liu Minmin Zhang Shuai Tang Bing Xiong Lanping Ma Meiyu Geng Jingkang Shen; supported financially by the National Science & Technology Major Project ‘Key New Drug Creation and Manufacturing Program’ of China(Grant No.2014ZX09507002);the National Marine ‘863’ Project(No.2013AA092902); Histone acetylation is a critical process in the regulation of chromatin structure and gene expression.Histone deacetylases(HDACs)remove the acetyl group,leading to chromatin condensation and transcriptional repressio...; 关键词：HISTONE DEACETYLASES INHIBITOR ANTICANCER TETRAHYDROISOQUINOLINE Structure–activity relationship

In vitro screening of 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines: structure related activity against pathogenic bacteria: 《Asian Pacific Journal of Tropical Biomedicine》2015年第6期471-475,共5页Moses Njutain Ngemenya Joelle Ngo Hanna Julios Armand Komtchou Simon Mbua Ngale Efange; Supported by Special Fund for the Modernisation of University Research in Cameroon,Presidential decree No 2009/121; Objective: To evaluate the antibacterial activity of ten synthetic tetrahydroisoquinolines against eight bacterial strains. Methods: The ten tetrahydroisoquinolines synthesized via base-catalyzed Pictet-Spengler cycli...; 关键词：ANTIBIOTICS DRUG discovery ANTIBACTERIAL agents TETRAHYDROISOQUINOLINES CYTOTOXICITY

Efficient and Practical Syntheses of Enantiomerically Pure (S)-(−)-Norcryptostyline Ⅰ, (S)-(−)-Norcryptostyline Ⅱ, (R)-(+)-Salsolidine and (S)-(−)-Norlaudanosine via a Resolution-Racemization Method被引量：1: 《Chinese Journal of Chemistry》2014年第10期1039-1048,共10页Ruiheng Zhu Zhangli Xu Wei Ding Shiling Liu Xiaoxin Shi Xia Lu; We thank the National Natural Science Foundation of China(No.20972048)for the financial support of this work.; Four racemic tetrahydroisoquinolines(RS)-(±)-1-4 were prepared from homoveratrylamine via amidation,Bischler-Napieralski reaction and the subsequent reduction.The enantiomerically pure tetrahydroisoquinolines(S)-(−)-...; 关键词：TETRAHYDROISOQUINOLINES norcryptostyline salsolidine norlaudanosine RESOLUTION RACEMIZATION

1-Chloromethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid amide, a derivative of tetrahydroisoquinoline, induces granulocytic differentiation of the human leukemic HL-60 cells via G0/G1 phase arrest: 《Health》2013年第5期1-7,共7页Sung-Min Ju Hyun-Ock Pae Won-Sin Kim Chai-Ho Lee Byung-Hun Jeon; Tetrahydroisoquinolines are known to have various biological effects, including antitumor activity. This study investigated the effect of 1-chloromethyl-6, 7-dimethoxy-3, 4-dihydro-1H-isoquinoline-2-sulfonic acid amid...; 关键词：Differentiation G0/G1 PHASE ARREST HL-60 Cells TETRAHYDROISOQUINOLINES P27Kip1

Synthesis and cytotoxicity of dinuclear platinum(Ⅱ) complexes of(1S,3S)-1,2,3,4-tetrahydroisoquinolines: 《Chinese Chemical Letters》2013年第3期186-188,共3页Geng Xu Ju Guo Zheng Yan Nan Wang Zhan-Zhu Liu; A series of novel dinuclear platinum（II） complexes with （IS, 3S）-l,2,3,4-tetrahydroisoquinolines as the ligands were synthesized as potential anticancer agents in several steps starting from commercially available...; 关键词：Dinuclear platinum（ll） complexesAntitumor activityTetrahydroisoquinolinesSynthesis

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