Early mortality of alcoholic hepatitis: A review of data from placebo-controlled clinical trials  

作　　者：Yu, Chao-Hui Xu, Cheng-Fu Ye, Hua Li, Lan Li, You-Ming 

机构地区：[1]Zhejiang Univ, Dept Gastroenterol, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China

出　　处：《World Journal of Gastroenterology》2010年第19期2435-2439,共5页世界胃肠病学杂志（英文版）

基　　金：Supported by Chinese State Key Project for High Technology, No. 2006AA02A308;National Key Technology R&D Program, No. 2008BAI52B03;Science and Technology Foundation of Zhejiang Province, No. 2008C13027-1

摘　　要：AIM: To investigate the early mortality of placebo-treated alcoholic hepatitis patients. METHODS: Mortality data about alcoholic hepatitis patients who participated in randomized placebo-controlled trials were searched from PubMed, EMBASE, and Cochrane Library, extracted and analyzed. RESULTS: A total of 661 placebo-treated patients in 19 trials were included. The overall mortality rate was 34.19% with a median observation time of 160 d (range 21-720 d). Hepatic failure, gastrointestinal bleeding and infection were the three main causes of death, accounting for 55.47%, 21.17% and 7.30% of all deaths, respectively. One-month mortality data about 324 placebo-treated alcoholic hepatitis patients in 10 trials were reported with a pooled mortality rate of 20.37%. The one-month mortality rate of patients with moderate to severe alcoholic hepatitis tended to be higherthan that of general patients (22.69% vs 10.93%, P < 0.05), whereas no signifi cant difference was observed between the patients from North America or Europe (22.43% vs 18.45%, P > 0.05), neither any difference was found between the studies published before and after 1990 (18.18% vs 21.88%, P > 0.05). CONCLUSION: Alcoholic hepatitis is a severe liver disease with a high mortality rate, and hepatic failure, gastrointestinal bleeding and infection are the three main causes of death.AIM: To investigate the early mortality of placebo-treated alcoholic hepatitis patients. METHODS: Mortality data about alcoholic hepatitis patients who participated in randomized placebo-controlled trials were searched from PubMed, EMBASE, and Cochrane Library, extracted and analyzed. RESULTS: A total of 661 placebo-treated patients in 19 trials were included. The overall mortality rate was 34.19% with a median observation time of 160 d (range 21-720 d). Hepatic failure, gastrointestinal bleeding and infect...

关 键 词：Alcoholic hepatitis MORTALITY PLACEBO 

分 类 号：R575.1[医药卫生—消化系统]