Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan  

作　　者：Sergio A Con Hiroaki Takeuchi Mitsuaki Nishioka Norihito Morimoto Tetsuro Sugiura Nobufumi Yasuda Reinaldo Con-Wong 

机构地区：[1]Centro Digestivo Doctores Con-Mediplaza, 245-1200 San José,Costa Rica [2]Department of Clinical Laboratory Medicine,Kochi Medical School, Kochi University,Nankoku-city,Kochi 783-8505,Japan [3]Department of Public Health,Kochi Medical School,Kochi University, Nankoku-city,Kochi 783-8505,Japan [4]Centro Digestivo Doctores Con-Mediplaza,245-1200 San José,Costa Rica

出　　处：《World Journal of Gastroenterology》2010年第4期474-478,共5页世界胃肠病学杂志（英文版）

基　　金：Supported by (in part) A Grant-in-Aid for Scientific Research from the Ministry of Education,Science and Culture of Japan(21590631);the Project Research Fund from the Kochi University

摘　　要：AIM:To evaluate the prevalence of Helicobacter pylori(H.pylori ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS:A total of 95 continuous H.pylori-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous H.pylori-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2005 to July 2006.They were enrolled for the polymerase chain reaction(PCR)-based genotyping of the H.pylori babA2 ,babB and babA2/B genes.Statistical analysis was performed using the χ2 test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age.P < 0.05 was regarded as statistically significant.RESULTS:The PCR-based genotyping of 95 Costa Rican and 95 Japanese isolates showed a higher prevalence of babA2 in Japan(96.8%) than in Costa Rica(73.7%),while that of babA2/B was higher in Costa Rica(11.6%) than in Japan(1.1%).In Costa Rican isolates only,babA2 was significantly associated with atrophic gastritis(P = 0.01).CONCLUSION:These results suggest that the status of babA2 and babA2/B shows geographic differences,and that babA2 has clinical relevance in Costa Rica.AIM:To evaluate the prevalence of Helicobacter pylori(H.pylori ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS:A total of 95 continuous H.pylori-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous H.pylori-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2...

关 键 词：BABA2 babA2/B Costa Rica Helicobacter pylori JAPAN 

分 类 号：R573[医药卫生—消化系统]