A dynamic model of once-daily 5-aminosalicylic acid predicts clinical efficacy  

作　　者：Deepak Parakkal Eli D Ehrenpreis Matthew P Thorpe Karson S Putt Bruce Hannon 

机构地区：[1]Department of Gastroenterology,North-Shore University Hospital [2]Chief of Gastroenterology and Endoscopy,Highland Park Hospital,NorthShore University Health System [3]Clinical Associate Professor of Medicine,University of Chicago [4]Division of Nutritional Sciences,University of Illinois [5]Department of Biochemistry,University of Illinois [6]Department of Geography/NCSA,University of Illinois

出　　处：《World Journal of Gastroenterology》2010年第1期136-137,共2页世界胃肠病学杂志（英文版）

摘　　要：New once daily mesalamine formulations may improve adherence to medication usage.Response to Asacol and other forms of 5-aminosalicyclic acid(5-ASA)is better correlated with tissue concentrations and best predicted by concentrations of the drug within the lumen of the colon.Our group used computer simulation to predict colonic 5-ASA levels after Asacol administration.In our study,the model simulated Asacol distribution in the healthy colon,and during quiescent and active ulcerative colitis.An Asacol dosage of 800 mg,threetimes a day,was compared to 2400 mg given once a day.Under ideal conditions,the predicted maximum drug in the total colon and individual colonic segments over 100 d differed by less than 3%between single and multiple doses.Despite changes in motility and defection rates,the predicted maximum and average 5-ASA concentrations in the total colon and individual colonic segments differed by less than 10%between dosing regimens.Asymmetric distribution of 5-ASA in the colon was influenced by frequency of bowel movements and colonic transit rate.In active colitis,sigmoid 5-ASA concentration becomes negligible.Our model supports once daily administration of Asacol as standard treatment for ulcerative colitis.New once daily mesalamine formulations may improve adherence to medication usage.Response to Asacol and other forms of 5-aminosalicyclic acid(5-ASA)is better correlated with tissue concentrations and best predicted by concentrations of the drug within the lumen of the colon.Our group used computer simulation to predict colonic 5-ASA levels after Asacol administration.In our study,the model simulated Asacol distribution in the healthy colon,and during quiescent and active ulcerative colitis.An Asacol dosage ...

关 键 词：Ulcerative colitis 5-aminosalicylate MESALAZINE Asacol ONCE-DAILY 

分 类 号：R96[医药卫生—药理学]