抑郁障碍的无抽搐电休克疗法前后非匹配负波研究  

Comparison of Mismatch Negativities in Patients with Depression before and after Modified Electroconvulsive Therapy

作　　者：徐水泉[1] 马俊[1] 王省堂[1] 张雷鸣[1] 梁锋[1] 陈冲[2] 

机构地区：[1]江西省精神病医院精神科,南昌330029 [2]上海交通大学医学院附属精神卫生中心电生理室,上海200030

出　　处：《神经病学与神经康复学杂志》2009年第4期274-276,共3页Journal of Neurology and Neurorehabilitation

摘　　要：目的探讨无抽搐电休克(MECT)治疗前后抑郁障碍患者非匹配负波(MMN)的特点。方法应用脑诱发电位仪,对31名正常人和33例抑郁障碍患者在MECT治疗前后进行了MMN检测。结果与正常对照组比较,抑郁障碍组的MMN潜伏期延迟和波幅降低[分别(202.1±32.1)ms和(8.0±3.8)μV,(224.3±35.0)ms和(5.6±3.5)μV,P均<0.01];抑郁障碍组P300中的靶指标P3潜伏期延迟、靶波幅P3降低(分别P<0.01和P<0.05)。抑郁障碍组经MECT治疗后的MMN波幅低。结论 MMN和P300联合应用可作为MECT治疗抑郁障碍监测的有临床意义的指标。Objective To investigate the effect of modified electroconvulsive therapy (MECT) on mismatch negativity(MMN) in patients with depression.Methods Using brain evoked potential instrument,the MMN was recorded in 31 normal controls(NC) and 33 depressive patients before and after MECT.Results Compared with NC,the depressive patients showed delayed MMN latency [NC(202.1±32.1)ms,the depression group(224.3±35.0)ms,P<0.01],decreased MMN amplitude [NC(8.0±3.8)μV,the depression group (5.6±3.5)μV,P<0.01],delayed ...

关 键 词：抑郁障碍 非匹配负波 无抽搐电休克 

分 类 号：R749.4[医药卫生—神经病学与精神病学]