微生物来源的免疫抑制剂生物合成基因簇的研究  

Biosynthesis gene cluster of immunodepressants derived from microorganisms

作　　者：陈怡倩[1] 胡海峰[1] 

机构地区：[1]上海医药工业研究院生物部,上海200040

出　　处：《世界临床药物》2009年第12期746-752,共7页World Clinical Drug

基　　金：国家科技支撑计划(2007BA129B04);重大新药创制"科技重大专项(2009ZX09301-007);上海市基础重点项目(08JC1418400)

摘　　要：微生物来源的免疫抑制剂因免疫抑制活性高,毒性及不良反应小而受到医药学研究及临床的日益关注。市场需求的增加带来了生产及临床上的诸多问题,对此类药物生物合成基因簇的研究是解决这些问题的创新性且具潜力的方法。本文综述目前临床用微生物来源的免疫抑制剂生物合成基因簇的研究价值及意义、研究历史、常用研究方法及应用前景。Immunodepressants derived from microorganisms have gained more and more interests from medicine research and clinic field because of their high activities and little toxicity as well as adverse reactions.Lots of problems on production and clinic usage of immunodepressants come with the market requirements at the same time.And the study of the biosynthesis gene cluster of immunodepressants can be an innovative and potential method to solve these problems. This article reviews the value,history and methods of...

关 键 词：免疫抑制剂 微生物 生物合成基因簇 雷帕霉素 他克莫司 子囊霉素 

分 类 号：R91[医药卫生—药学]