TP诱导化疗后同期放化疗治疗局部晚期鼻咽癌27例的Ⅱ期临床试验  

A Phase Ⅱ Clinical Trial of Concurrent Chemoradiotherapy after Induction Chemotherapy with TP Regimen in the Treatment for 27 Cases with Locally Advanced Nasopharyngeal Carcinoma

作　　者：邹国荣[1] 谢方云[2] 曹小龙[1] 李济时[2] 彭苗[2] 

机构地区：[1]广州市番禺中心医院,广东广州511460 [2]华南肿瘤学国家重点实验室中山大学肿瘤防治中心,广东广州510060

出　　处：《肿瘤学杂志》2009年第12期1100-1104,共5页Journal of Chinese Oncology

摘　　要：[目的]探索TP方案诱导化疗后DDP同期放化疗治疗局部晚期鼻咽癌的疗效、毒副反应。[方法]2005年12月至2006年12月,27例T3~4N2~3M0鼻咽癌患者纳入试验。诱导化疗采用TP方案(docetaxel 70mg/m2,d1;DDP 80mg/m2,d2),每3周1次,共2个周期。同期化疗采用DDP80mg/m2,d1;放疗采用直线加速器,CT-Sim技术,常规分割。[结果]TP诱导化疗毒副反应主要为血液毒性,同期放化疗毒副反应主要为血液毒性和口腔黏膜反应。TP诱导化疗后鼻咽部病灶缓解率66.7%,区域淋巴结缓解率78.8%。同期放化疗后鼻咽部病灶及区域淋巴结缓解率为100%,其中鼻咽部病灶完全缓解率96.3%;区域淋巴结完全缓解率91.3%。患者1年OS、PFS均为100%。[结论]TP方案诱导化疗后,DDP同期放化疗的毒副反应患者能耐受,近期疗效好。[Purpose]To study the short-term response and toxicity of concurrent chemoradiotherapy with cisplatin(DDP)after induction chemotherapy with TP regimen in the treatment for locally advanced nasopharyngeal carcinoma(NPC).[Methods]Twenty-seven cases with stage T3~4N2~3M0 nasopharyngeal carcinoma from December 2005 to December 2006 were enrolled.All patients received TP regimen as induction chemotherapy with docetaxel 70mg/m2 and DDP 80mg/m2,repeating every 21 days for 2 cycles,and concurrent chemotherapy with ...

关 键 词：鼻咽肿瘤 药物疗法 多西紫杉醇 顺铂 

分 类 号：R739.63[医药卫生—肿瘤]