Novel ultrasound contrast agents——Biodegradable poly(lactic acid)microcapsules  

作　　者：王身国 崔文瑾 李光明 蔡晴 智光 赵玉英 杨波 徐勇 

机构地区：[1]Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China [2]General Hospital of Peoples Liberation Army, Beijing 100853, China

出　　处：《Science China Chemistry》2003年第4期371-378,共8页中国科学（化学英文版）

基　　金：supported by the National Basic Science Research and Development Funds(973).

摘　　要：As a novel ultrasound diagnostic contrast agent, the preparation, characterization and ultrasound imaging in the body of dog about poly(lactic acid) (PLLA) microcapsules have been studied. The behavior of this kind of contrast agent in the microcirculation was also investigated. Prepared by (water/oil/water) emulsion-solvent evaporation protocol, the PLLA microcapsules with hollow structure can enhance the ultrasound image both in vitro and in vivo, and the enduring time can last as long as 3 h. The microcirculation examination shows that the PLLA microcapsules with a diameter ranging from 2 to 8 mm could pass through the pulmonary capillaries without retention. All the results prove the PLLA microcapsules for potential use for the clinical application.As a novel ultrasound diagnostic contrast agent, the preparation, characterization and ultrasound imaging in the body of dog about poly(lactic acid) (PLLA) microcapsules have been studied. The behavior of this kind of contrast agent in the microcirculation was also investigated. Prepared by (water/oil/water) emulsion-solvent evaporation protocol, the PLLA microcapsules with hollow structure can enhance the ultrasound image both in vitro and in vivo, and the enduring time can last as long as 3 h. The microcirculation examination shows that the PLLA microcapsules with a diameter ranging from 2 to 8 mm could pass through the pulmonary capillaries without retention. All the results prove the PLLA microcapsules for potential use for the clinical application.

关 键 词：poly(lactic acid)  microcapsules  CONTRAST agent  ultrasound diagnosis  BLOOD filters. 

分 类 号：R445.1[医药卫生—影像医学与核医学]