老年人脑腔隙梗死与胰岛素抵抗关系的临床研究  

Correlation Between Brain Lacunar Infarction And Insulin-Resistance In elderly

作　　者：余玲玲[1] 陈治卿[1] 陈健[1] 周乃珍[1] 卓越[1] 李永忠[1] 梁立新[1] 林伯庚[1] 林纯毅[1] 

机构地区：[1]厦门大学医学院第一临床学院厦门中山医院,361000

出　　处：《中国老年保健医学》2003年第3期12-15,共4页Chinese Journal of Geriatric Care

摘　　要：目的探讨老年人脑腔隙梗死(腔梗)与胰岛素抵抗(IR)的关系。方法对354例受试者行空腹血糖(FPG)、甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)检测。采用放免法测定空腹胰岛素(FIN)。评估机体胰岛素抵抗(HOMA-IR),并计算其体重指数(BMI)。将腔梗组按无、有高血压及高 TG/低 HDL 分为Ⅰ、Ⅱ两组。结果腔梗组与健康对照组比较 TG,TC、LDL、FIG、FIN、HOMA-IR 有非常显著差异(P<0.01)。在校正年龄、性别、BMI 后老年人腔梗仍有显著的 IR,且不受高血压和高 TG 的影响。结论老年人腔梗较健康老人有明显的 IR。高 TG、高 LDL、IR 是影响老年人腔梗的可能是独立的危险因素,老年人腔梗与 IR 关系密切,呈正相关。Objective To explore the correlation between brain lacunar infarction and insulin-resistance(IR)in elderly.Methods Fasting blood-glucose(FPG), triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C), and low-density lipoprotein cholesterol(LDL-C)were tested in 354 subjects,and fasting insulin was tested with radioimmunoassay.The organic insulin resistance HOMAIR was eval- uated,and its body mass index(BMI)was calculated.The brain lacunar infarctions were di- vided into tow groups:High TG/low HDL with or without hypertension.Results There was very significant differences(P<0.01)in TG,TC,LDL,FPG,FIN,and HOMA-IR between brain lacunar infarction and health contrast groups.After modification in age,sex and BMI,there still existed significant IR.And brain lacunar infarction and insulin-resis- tance(IR)in elderly was not correlated with hypertension or high TG.Conclusions There is significant IR in elderly with brain lacunar infarction compared with healthy elders. High TG、high LDL、IR are the independent risk factors correlated with senile lacunar infarc- tion.There exists positive correlation between senile lacunar infarction and IR.

关 键 词：老年人 腔隙梗塞 胰岛素抵抗 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R587[医药卫生—临床医学]