肿瘤相关抗原CA15-3在胃癌组织中的表达及其意义  

The Expression and Significance of CA15 -3 in Gastric Carcinoma

作　　者：吴翰桂[1] 

机构地区：[1]台州学院生命科学与医药化工学院,浙江临海317000

出　　处：《台州学院学报》2003年第3期62-64,共3页Journal of Taizhou University

摘　　要：应用免疫组织化学SP法检测胃癌组织及同一患者相应正常胃粘膜组织中CA15-3的表达情况。结果显示:20例胃癌组织中阳性表达者15例,而正常胃粘膜均为阴性。这表明CA15-3的表达与胃癌之间存在明显的相关性,CA15-3阳性表达可能是胃癌变细胞的标志之一。CA15-3阳性表达及胞浆阳性定位与与胃癌进展,浸润深度,淋巴结转移无关,但与胃癌分化程度呈负相关。S - P immunohistochemical technique is adapted to detect the expression of CA15 - 3 in gastric carcinoma tissues and paired normal gastric mucosa from 20 gastric cancer patients. The results indicates that CA15 - 3 protein is expressed in 15 cases of these 20 gastric carcinoma tissues, but no expression is found in normal gastric mucosa. There is a significant relationship between the expression of CA15 -3 protein and the differentiation degree,but no statistical relationship can be found between the expression of CA15 -3 protein and the stage or aggressive depth. These results suggest that the detection of CA15 -3 can be used as a guideline for gastric cancer patients'expectation.

关 键 词：胃癌 肿瘤相关抗原CAl5-3 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]