Effects of extremely low frequency magnetic fields on gap junctional intercellular communication and its mechanism  

作　　者：CHIANG Huai , HU Genlin and XU Zhengping(Microwave Laboratory, Zhejiang University School of Medicine, Hangzhou 310031, China) 

出　　处：《Progress in Natural Science:Materials International》2002年第3期166-169,共4页自然科学进展·国际材料（英文版）

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 39630100)

摘　　要：The study on biological effect of electromagnetic fields has been paid close attention in recent years. Gap junctional intercellular communication (GJIC) plays an important role in the maintenance of cell proliferation and differentiation, and in the multistage process of carcinogenesis. A series of researches showed that xtremely low frequency (ELF) magnetic fields not only enhance the inhibition of GJIC induced by 12-O-tetradecanoylphorbol-13-acetate, but also inhibit GJIC directly when the intensity is equal to or more than 0.4 　mT, and that the mechanisms of GJIC inhibition by ELF magnetic fields are due to hyperphosphorylation of connexin 43, which is mediated by protein kinase C-activated signal transduction, and the internalization of connexin 43 from plasma membrane to cytoplasm.The study on biological effect of electromagnetic fields has been paid close attention in recent years, Gap junctional intercellular communication (GJIC) plays an important role in the maintenance of cell proliferation and differentiation, and in the multistage process of carcinogenesis. A series of researches showed that extremely low frequency (ELF) magnetic fields not only enhance the inhibition of GJIC induced by 12 -O- tetradecanoylphorbot-13-acetate, but also inhibit GJIC directly when the intensity is equal to or more than 0.4 mT, and that the mechanisms of GJIC inhibition by ELF magnetic fields are due to hyperphosphorylation of connexin 43, which is mediated by protein kinase C-activated signal transduction, and the internalization of connexin 43 from plasma membrane to cytoplasm.

关 键 词：EXTREMELY low frequency magnetic fields  GAP JUNCTIONAL INTERCELLULAR communication  mechanism. 

分 类 号：Q27[生物学—细胞生物学]