INTERCELLULAR

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Exosomal mediators in sepsis and inflammatory organ injury:unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
《Military Medical Research》2025年第2期264-284,共21页Ting Gong You-Tan Liu Jie Fan 
USA National Institutes of Health Grant(R01-HL-139547,to JF);USA VA Grants(1I01BX004838 and IK6BX004211,to JF);National Natural Science Foundation of China(82002087,to TG);Shenzhen Science and Technology Program(JCYJ20210324134602008,to TG)。
Sepsis,a severe systemic inflammatory response to infection,remains a leading cause of morbidity and mortality worldwide.Exosomes,as mediators of intercellular communication,play a pivotal role in the pathogenesis of ...
关键词：SEPSIS EXOSOMES Intercellular crosstalk Inflammation Biomarkers 
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit
《Protein & Cell》2024年第12期906-929,共24页Hao Wang Junbo Yang Yihong Cai Yang Zhao 
supported by the National Key Research and Development Program of China(2018YFA0800504);the National Natural Science Foundation of China(31922020);funding provided by Plastech Pharmaceutical Technology Co.,Ltd.
Direct conversion of cardiac fibroblasts(CFs)to cardiomyocytes(CMs)in vivo to regenerate heart tissue is an attractive approach.After myocardial infarction(MI),heart repair proceeds with an inflammation stage initiate...
关键词：cardiac reprogramming heart regeneration microenvironment Ifnar1/2 
Correction to: Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit
《Protein & Cell》2024年第12期938-938,共1页
This is a correction to:Hao Wang,Junbo Yang,Yihong Cai,Yang Zhao,Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFNmediated intercellular self-stimulating circuit,Protein&Cell,2024;pwae013,https...
关键词：programming stimulating vivo 
Nanomedicine regulating PSC-mediated intercellular crosstalk:Mechanisms and therapeutic strategies
《Acta Pharmaceutica Sinica B》2024年第11期4756-4775,共20页Hui Wang Liang Qi Han Han Xuena Li Mengmeng Han Lei Xing Ling Li Hulin Jiang 
National Key R&D Program of China(2022YFE0198400);National Natural Science Foundation Major International(Regional)Joint Research Program(Nos.82020108029,82320108003,China);National Natural Science Foundation(Nos.82170845,82073398,82003677,82000740,81970717,China);Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University(SKLNMZZ202021,China);“111”Project from the Ministry of Education of China,the State Administration of Foreign Experts Affairs of China(B16046);Double First-Rate construction plan of China Pharmaceutical University(CPU2018GY06,CPU2022QZ18,China);Key Research&Development Program(BE2022853,China);Medical Key Discipline(ZDXK202203,China)of Jiangsu Province.
Pancreatic fibrosis(PF)is primarily distinguished by the stimulation of pancreatic stellate cells(PSCs)and excessive extracellular matrix deposition,which is the main barrier impeding drug delivery and distribution.Re...
关键词：NANOMEDICINE Pancreatic fibrosis Pancreatic stellatecell Intercellularcrosstalk PANCREATITIS Pancreatic cancer Diabetes Therapeutic strategies 
Identification of immune feature genes and intercellular profiles in diabetic cardiomyopathy
《World Journal of Diabetes》2024年第10期2093-2110,共18页Ze-Qun Zheng Di-Hui Cai Yong-Fei Song 
Supported by National Natural Science Foundation of China,No.82300347;Natural Science Foundation of Ningbo,No.2021J296;Science Foundation of Lihuili Hospital,No.2022ZD004.
BACKGROUND Diabetic cardiomyopathy(DCM)is a multifaceted cardiovascular disorder in which immune dysregulation plays a pivotal role.The immunological molecular mechanisms underlying DCM are poorly understood.AIM To ex...
关键词：Diabetic cardiomyopathy Immune feature genes PROENKEPHALIN Retinol binding protein 7 Immune cell infiltration Intercellular communication 
Effects of different doses of glucose and fructose on central metabolic pathways and intercellular wireless communication networks in humans
《Food Science and Human Wellness》2024年第4期1906-1916,共11页Dingqiang Lu Yujiao Liu Miao Zhao Shuai Yuan Danyang Liu Xinqian Wang Yixuan Liu Yifei Zhang Ming Li Yufeng Lü Guangchang Pang Ruijuan Ren 
financially supported by National Natural Science Foundation of China(31901782)。
Fructose and glucose are often widely used in food processing and may contribute to many metabolic diseases.To observe the effects of different doses of glucose and fructose on human metabolism and cellular communicat...
关键词：FRUCTOSE GLUCOSE Central carbon metabolic pathway Metabolic enzymes Cytokine network 
Protective and Regenerative Efficacy of a Plant Oil-Based Day and Night Cream: Investigated by a Novel Approach to Reveal the Impact of Blue Light Irradiation on Epidermal Barrier Integrity and Lipid Matrix
《Journal of Cosmetics, Dermatological Sciences and Applications》2024年第3期227-241,共15页Dorothee Dähnhardt Stephan Dähnhardt-Pfeiffer Isabel Simon Dana Ditgen Inge Holland Dörte Segger Peter Staib 
In recent years, the harmful effects of blue light (400 - 500 nm) as a component of visible light (400 - 700 nm) have increasingly gained attention of science, industry, and consumers. To date, only a few in vivo test...
关键词：Skin Care Blue Light Irradiation Skin Barrier Intercellular Lipid Lamellae Electron Microscopy 
Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China
《Frigid Zone Medicine》2024年第2期102-109,共8页Jiaxin Guan Lu Gan Chaoqi Yan Boyu Hou Ying Fan 
This work was supported by the National Natural Science Foundation of Heilongjiang Province of China(No.LH2020H051);Key R&D projects of Natural Science Foundation of Heilongjiang Province(No.2023ZX06C03);Foundation of Harbin Science Technology Bureau of China(No.2014RFQGJ042).
Background and objective:Commonly plaguing in the frigid zone of the world,vitamin D deficiency,as indicated by low levels of 25-hydroxyvitamin D,exacerbated inflammatory responses and impaired endothelial function.Le...
关键词：cerebral small vascular disease degenerative disease LEUKOARAIOSIS white matter hyperintensities lacunar infarction 25-hydroxyvitamin D ICAM-1 fibrinogen-C inflammatory factor fazekas scale 
Extracellular vesicles:A new frontier in the theranostics of cardiovascular diseases
《iRADIOLOGY》2024年第3期240-259,共20页Enze Fu Zongjin Li 
Research Project on Skin Injury&Repair,Grant/Award Numbers:2021XB008,BKJ21J016;Tianjin Natural Science Foundation,Grant/Award Numbers:21JCZDJC00070,22JCZXJC00170;Nankai University Eye Institute,Grant/Award Number:NKYKD202203。
Extracellular vesicles(EVs)are tiny vesicles released by various cells that contain a variety of proteins,lipids,and nucleic acids,which can have a wide range of effects on other cells.The dynamic composition and cont...
关键词：CARDIOVASCULAR diseases (CVDs) EXTRACELLULAR vesicles (EVs) INTERCELLULAR communication targeted delivery THERANOSTICS 
Intercellular transfer of multidrug resistance mediated by extracellular vesicles
《Cancer Drug Resistance》2024年第1期403-418,共16页Anxiang Yang Hui Sun Xiaokun Wang 
supported by the Fundamental Research Funds for Hainan University[KYQD(ZR)23146,China].
Multidrug resistance(MDR)poses a formidable obstacle in cancer treatment,enabling cancer cells to evade the cytotoxic effects of chemotherapeutic drugs through various mechanisms.These mechanisms include intrinsic res...
关键词：Multidrug resistance extracellular vesicles intercellular transfer intercellular communication ABC transporter 
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