Intercellular transfer of multidrug resistance mediated by extracellular vesicles  

作　　者：Anxiang Yang Hui Sun Xiaokun Wang 

机构地区：[1]Key Laboratory of Tropical Biological Resources of Ministry of Education,School of Pharmaceutical Sciences,Hainan University,Haikou 570228,Hainan,China [2]School of Life and Health Sciences,Hainan University,Haikou 570228,Hainan,China

出　　处：《Cancer Drug Resistance》2024年第1期403-418,共16页癌症耐药(英文)

基　　金：supported by the Fundamental Research Funds for Hainan University[KYQD(ZR)23146,China].

摘　　要：Multidrug resistance(MDR)poses a formidable obstacle in cancer treatment,enabling cancer cells to evade the cytotoxic effects of chemotherapeutic drugs through various mechanisms.These mechanisms include intrinsic resistance,which is present prior to treatment,and acquired resistance,which develops after exposure to chemotherapy agents.Small membrane-bound vesicles,known as extracellular vesicles(EVs),are crucial in intercellular signaling as they transport bioactive molecules that can modify the characteristics and functions of recipient cells.Recent research highlights EVs as pivotal players in fostering drug resistance.This review focuses on the intercellular transfer of MDR from donor cells to susceptible recipient cells through specific cargo in EVs,such as ATP-binding cassette(ABC)transporter proteins,nucleic acids,and other regulatory factors.Additionally,the features of intercellular communication mediated by EVs are also discussed.Gaining insight into these mechanisms is essential for developing strategies to counteract resistance and improve the effectiveness of cancer treatments.

关 键 词：Multidrug resistance extracellular vesicles intercellular transfer intercellular communication ABC transporter 

分 类 号：R73[医药卫生—肿瘤]