LEUKOARAIOSIS

作品数：15被引量：37H指数：4
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相关领域：医药卫生更多>>
相关作者：齐冬魏微黄勇华王晨李莹更多>>
相关机构：首都医科大学河北省人民医院北京军区总医院更多>>
相关期刊：《Frigid Zone Medicine》《Stroke & Vascular Neurology》《Neural Regeneration Research》《Discussion of Clinical Cases》更多>>
相关基金：国家自然科学基金上海市自然科学基金更多>>
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Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China
《Frigid Zone Medicine》2024年第2期102-109,共8页Jiaxin Guan Lu Gan Chaoqi Yan Boyu Hou Ying Fan 
This work was supported by the National Natural Science Foundation of Heilongjiang Province of China(No.LH2020H051);Key R&D projects of Natural Science Foundation of Heilongjiang Province(No.2023ZX06C03);Foundation of Harbin Science Technology Bureau of China(No.2014RFQGJ042).
Background and objective:Commonly plaguing in the frigid zone of the world,vitamin D deficiency,as indicated by low levels of 25-hydroxyvitamin D,exacerbated inflammatory responses and impaired endothelial function.Le...
关键词：cerebral small vascular disease degenerative disease LEUKOARAIOSIS white matter hyperintensities lacunar infarction 25-hydroxyvitamin D ICAM-1 fibrinogen-C inflammatory factor fazekas scale 
Overview-Research Progress of Leukoaraiosis
《Journal of Behavioral and Brain Science》2022年第11期599-626,共28页Yuanhao Chen Ying Bian 
In 1987, Hachinski et al. [1] proposed Leukoaraiosis (LA) as an imaging academic term. Since then, LA and other cerebrovascular diseases have become the research focus of scholars at home and abroad. However, the mole...
关键词：Leukoaraiosis (LA) Cerebral Small Vessel Disease Large Artery Atherosclerosis 
Cognitive Functional Impairment and Hemodynamic Changes in Patients with Symptomatic Leukoaraiosis被引量：1
《Journal of Behavioral and Brain Science》2022年第6期271-286,共16页Yuanhao Chen Yujiao Lin Ying Bian 
Objective: The pathogenesis of leukoaraiosis is still unclear. Many studies have determined that changes in the hemodynamics associated with leukoaraiosis, impaired cerebrovascular reserve, and intracranial hypoperfus...
关键词：LEUKOARAIOSIS Cerebral Hemodynamics Transcranial Doppler Ultrasound Breath-Holding Test Peak Type Middle Cerebral Artery Cognitive Function Executive Function 
Leukoaraiosis is associated with clinical symptom severity,poor neurological function prognosis and stroke recurrence in mild intracerebral hemorrhage:a prospective multi-center cohort study被引量：5
《Neural Regeneration Research》2022年第4期819-823,共5页Tian-Qi Xu Wei-Zhi Lin Yu-Lan Feng Fan-Xia Shen Jie Chen Wei-Wen Wu Xiao-Dong Zhu Lin Gu Yi Fu 
supported by the National Natural Science Foundation of China,Nos.81771281(to FXS),81471177(to FXS);the Natural Science Foundation of Shanghai of China,No.20ZR1434200(to YF)。
Leukoaraiosis(LA)results from ischemic injury in small cerebral vessels,which may be attributable to decreased vascular density,reduced cerebrovascular angiogenesis,decreased cerebral blood flow,or microcirculatory dy...
关键词：clinical symptom severity functional dependence intracerebral hemorrhage LEUKOARAIOSIS modified Rankin scale National Institute Health of Stroke Scale PROGNOSIS stroke recurrence white matter hyperintensities 
sTWEAK is a marker of early haematoma growth and leukoaraiosis in intracerebral haemorrhage被引量：4
《Stroke & Vascular Neurology》2021年第4期528-535,I0011,I0012,共10页Andrés da Silva-Candal Iria López-Dequidt Manuel Rodriguez-Yañez PauloÁvila-Gómez JoséManuel Pumar JoséCastillo Tomás Sobrino Francisco Campos Ramón Iglesias-Rey Pablo Hervella 
This study was partially supported by grants from the Spanish Ministry of Science and Innovation(SAF2017-84267-R);Xunta de Galicia(Axencia Galega de Innovación(GAIN):IN607A2018/3);Instituto de Salud Carlos III(ISCIII)(PI17/00540,PI17/01103);Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS PLUS(RD16/0019);by the European Union FEDER program.T.Sobrino(CPII17/00027),F.Campos(CPII19/00020)are recipients of research contracts from the Miguel Servet Program(Instituto de Salud Carlos III).
Objective To study the association between early growth of haematoma with biomarkers of endothelial dysfunction such as leukoaraiosis(LA)and the soluble tumour necrosis factor-like weak inducer of apoptosis(sTWEAK)in ...
关键词：TWEAK INTRACEREBRAL SPECIFICITY 
DDAH2(-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study
《Neural Regeneration Research》2021年第8期1592-1597,共6页Ying Fan Qiang Gao Jia-Xin Guan Lei Liu Ming Hong Li Jun Li Wang Hai-Feng Ding Li-Hong Jiang Bo-Yu Hou Mei Li Zhi-Qiang Song De-Qin Sun Chao-Qi Yan Lan Ma 
supported by the Foundation of Harbin Science Technology Bureau of China,No. 2014RFQGJ042 (to YF);Harbin Medical University Scientific Research Innovation Fund of China,No. 2016LCZX06 (to QG);the Natural Science Foundation of Heilongjiang of China,No. H2016027 (to QG)。
Cerebrovascular endothelial dysfunction is involved in the progression of leukoaraiosis. Asymmetric dimethylarginine is a competitive inhibitor of nitric oxide, which is highly expressed in patients with leukoaraiosis...
关键词：LEUKOARAIOSIS dimethylarginine dimethylaminohydrolase 2 gene polymorphism ALLELE asymmetric dimethylarginine nitric oxide endothelial dysfunction cerebrovascular diseases clinical trial 
A Study on the Correlation Between Cerebral Small Vascular Disease and Constitution Types of Traditional Chinese Medicine
《World Journal of Integrated Traditional and Western Medicine》2020年第11期7-14,共8页WANG Lian ZENG Rong FENG Hao-li LI Lin ZHAO Liang 
Objective:To study the correlation between cerebral small vascular disease and constitution types of Traditional Chinese Medicine(TCM).Methods:The severity of lacunar infarction and leukoaraiosis were graded in 230 pa...
关键词：Cerebral small vascular diseas Lacunar infarction LEUKOARAIOSIS Constitutional types of traditional Chinese medicine Risk factors 
Assessment of cerebrovascular reserve impairment using the breath-holding index in patients with leukoaraiosis被引量：5
《Neural Regeneration Research》2019年第8期1412-1418,共7页Ying Bian Jin-Chun Wang Feng Sun Zi-Yi Sun Yu-Jiao Lin Yang Liu Bin Zhao Li Liu Xiao-Guang Luo 
Many studies have demonstrated that leukoaraiosis is associated with impaired cerebrovascular reserve function. However, the definitive hemodynamic changes that occur in leukoaraiosis are not clear, and there are many...
关键词：nerve REGENERATION CEREBRAL small vascular disease white matter HYPERINTENSITIES CEREBRAL hemodynamics CEREBRAL hypoperfusion middle CEREBRAL artery blood flow velocity breath-holding test breath-holding index cognitive function neural REGENERATION 
Predicting Mortality and Functional Outcomes after Ischemic Stroke: External Validation of a Prognostic Model
《Journal of Behavioral and Brain Science》2018年第10期587-597,共11页Achala Vagal Heidi Sucharewv Christopher Lindsell Dawn Kleindorfer Kathleen Alwell Charles J. Moomaw Daniel Woo Matthew Flaherty Pooja Khatri Opeolu Adeoye Simona Ferioli Jason Mackey Sharyl Martini Felipe De Los Rios La Rosa F. Brett Kissela 
Background: We previously developed predictive models for 3-month mortality and modified Rankin Score (mRS) after ischemic stroke. Aim: The aim was to test model validity for 3-month mortality and mRS after ischemic s...
关键词：ISCHAEMIC STROKE EPIDEMIOLOGY STROKE LEUKOARAIOSIS AFRICAN American STROKE Prevalence 
Generation of genetically modified olfactory ensheathing cells that secrete VEGF: Potential application in cell-based treatment of leukoaraiosis
《Translational Neuroscience and Clinics》2017年第2期104-110,共7页Chuanqiang Qu Yuanyuan Zhao Qinjian Sun Yifeng Du 
Supported by the National Natural Science Foundation of China(Grant No.30970991);Critical R&D Project of Shandong Province,2015(Grant No.2015GSF118069)
Objective: We aimed to provide an alternative cell source for cell therapy in leukoaraiosis(LA). Methods: Olfactory ensheathing cells(OECs) from the olfactory bulb were isolated,cultured, and purified. Next, the lenti...
关键词：olfactory ensheathing cells vascular endothelial growth factor genetically engineered cells 
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