Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China  

作　　者：Jiaxin Guan Lu Gan Chaoqi Yan Boyu Hou Ying Fan 

机构地区：[1]Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China [2]The Physical examination center of the Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China

出　　处：《Frigid Zone Medicine》2024年第2期102-109,共8页寒地医学（英文）

基　　金：This work was supported by the National Natural Science Foundation of Heilongjiang Province of China(No.LH2020H051);Key R&D projects of Natural Science Foundation of Heilongjiang Province(No.2023ZX06C03);Foundation of Harbin Science Technology Bureau of China(No.2014RFQGJ042).

摘　　要：Background and objective:Commonly plaguing in the frigid zone of the world,vitamin D deficiency,as indicated by low levels of 25-hydroxyvitamin D,exacerbated inflammatory responses and impaired endothelial function.Leukoaraiosis(LA)is a prevalent cause of cognitive dysfunction in the elderly and is potentially associated with inflammatory responses.This study aimed to investigate the impact of vitamin D on the severity of LA.Methods:Patients with LA were categorized based on 3.0 T brain MRI findings into mild(N=43),moderate(N=40),or severe groups(N=29)using the Fazekas scale(scoring 1-6).A control group consisting of 41 healthy individuals was included.Serum fibrinogen C,homocysteine,plasma 25-hydroxyvitamin D,and intercellular cell adhesion molecule-1(ICAM-1)levels were measured using ELISA.Results:All LA severity groups exhibited lower plasma 25-hydroxyvitamin D levels compared to the control group,with a more pronounced decrease observed as LA severity increased.Low plasma 25-hydroxyvitamin D was identified as an independent risk factor for LA(P<0.05)according to Multiple logistic regression analysis.Additionally,a negative association was observed between 25-hydroxyvitamin D and vascular inflammatory factor ICAM-1.Conclusions:Disease severity positively correlated with levels of the inflammatory marker ICAM-1,worsening as plasma 25-hydroxyvitamin D concentration decreased.Low 25-hydroxyvitamin D emerged as an independent risk factor for LA,potentially exacerbating the inflammatory response.These findings suggest 25-hydroxyvitamin D supplementation as a potential therapeutic approach for LA.

关 键 词：cerebral small vascular disease degenerative disease LEUKOARAIOSIS white matter hyperintensities lacunar infarction 25-hydroxyvitamin D ICAM-1 fibrinogen-C inflammatory factor fazekas scale 

分 类 号：R581[医药卫生—内分泌]