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作 者:李海刚[1] 曾韵洁[1] 沈溪明[1] 吴东霞[1] 苏逢锡[2] 贾渭娟[2]
机构地区:[1]中山大学附属第二医院病理科,广州510120 [2]中山大学附属第二医乳腺外科,广州510120
出 处:《岭南现代临床外科》2002年第4期223-225,共3页Lingnan Modern Clinics in Surgery
基 金:广东省科委重点攻关资助项目(99M04914G)
摘 要:目的 研究乳腺癌患者腋窝非哨兵淋巴结(non-sentinel lymph node,NSLN)跳跃式转移的相关临床病理因素。方法 观察 8例行根治性乳房切除、腋窝哨兵淋巴结活检(sentinel lymph node biopsy,SLNB)和腋窝淋巴结(axillary lymph node,ALN)清扫术(ALN dissection,ALND)后病理组织学检查证实为 NSLN跳跃式转移的乳腺癌患者,对肿瘤原发灶的病理组织学特点、雌孕激素受体的表达和ALN窦组织细胞(SH)、生发中心增生(GH)和副皮质区增生(PH)等情况进行分析。结果 8例乳腺癌原发灶有一些共同的病理组织学特点;伴癌转移的 NSLN SH、PH的程度明显低于其他组 LN,且纤维化的发生率(占 85.0%)明显高于其他组(0)。伴癌转移NSLN之间的大小、癌所占的面积等相差较大。结论 NSLN跳跃式转移与癌原发灶、NSLN的病理组织学改变有关。Objective To investigate the related clinical pathological factors of breast carcinoma with skip metastasis to non sentinel lymph node (NSLN) . Method Scases with skip metastasis to NSLN of breast cancer were confirmed by pathohistological examination after radical mastectomy, sentinel lymph node biopsy (SLNB) and axillary lymph node dissection. The pathohistological features of primary lesion, expression of ER/PgR, sinosoidal tissue celi hyperplasia (SH), Germinal center hyperplasia (GH) of the axillary lymph node and paracortical area hyperplasia(PH) were analyzed retrospectively. Results Some common features of the pathohistology were found in 8 case of the primary lesion of breast cancer. The degree of SH, PH of NSLN were lower obviously than other group LN and accidence of fibrosis was higher obviously than other group. There were obvious difference between the NSLN associated with cancerous metastasis in size and cancer occupying area. Conclusion The skip metastasis to NSLN of the breast cancer correlated with the cancerous primary lesion and pathohistological change of NSLN.
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